ID I3XZT4_SULBS Unreviewed; 476 AA.
AC I3XZT4;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Aspartate ammonia-lyase {ECO:0000256|ARBA:ARBA00016146, ECO:0000256|RuleBase:RU362017};
DE Short=Aspartase {ECO:0000256|RuleBase:RU362017};
DE EC=4.3.1.1 {ECO:0000256|ARBA:ARBA00012992, ECO:0000256|RuleBase:RU362017};
GN OrderedLocusNames=Sulba_2183 {ECO:0000313|EMBL:AFL69458.1};
OS Sulfurospirillum barnesii (strain ATCC 700032 / DSM 10660 / SES-3).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Sulfurospirillaceae; Sulfurospirillum.
OX NCBI_TaxID=760154 {ECO:0000313|EMBL:AFL69458.1, ECO:0000313|Proteomes:UP000006176};
RN [1] {ECO:0000313|EMBL:AFL69458.1, ECO:0000313|Proteomes:UP000006176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700032 / DSM 10660 / SES-3
RC {ECO:0000313|Proteomes:UP000006176};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Lu M., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Stolz J., Arkin A.,
RA Dehal P., Oremland R., Saltikov C., Basu P., Hollibaugh J., Newman D.,
RA Stolyar S., Hazen T., Woyke T.;
RT "Complete sequence of Sulfurospirillum barnesii SES-3.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-aspartate = fumarate + NH4(+); Xref=Rhea:RHEA:16601,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:29806, ChEBI:CHEBI:29991; EC=4.3.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001494,
CC ECO:0000256|RuleBase:RU362017};
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family.
CC Aspartase subfamily. {ECO:0000256|ARBA:ARBA00005596,
CC ECO:0000256|RuleBase:RU362017}.
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DR EMBL; CP003333; AFL69458.1; -; Genomic_DNA.
DR RefSeq; WP_014770323.1; NC_018002.1.
DR AlphaFoldDB; I3XZT4; -.
DR STRING; 760154.Sulba_2183; -.
DR KEGG; sba:Sulba_2183; -.
DR PATRIC; fig|760154.4.peg.2185; -.
DR eggNOG; COG1027; Bacteria.
DR HOGENOM; CLU_021594_4_1_7; -.
DR OrthoDB; 9802809at2; -.
DR Proteomes; UP000006176; Chromosome.
DR GO; GO:0008797; F:aspartate ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0006531; P:aspartate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01357; Aspartase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR004708; ApsA.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00839; aspA; 1.
DR PANTHER; PTHR42696; ASPARTATE AMMONIA-LYASE; 1.
DR PANTHER; PTHR42696:SF2; ASPARTATE AMMONIA-LYASE; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU362017, ECO:0000313|EMBL:AFL69458.1}.
FT DOMAIN 16..342
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 408..461
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 476 AA; 51958 MW; 7F422ECB5FEDFF51 CRC64;
MSTRIEHDLI GDKEISNECY YGVQTARAAE NFHITGVTLS KFPTFIESIA KVKLAAALAN
YELGLLTEAK KNAIVEACDQ LIAGKHHNQF VVDMIQGGAG TSTNMNANEV IANIGLELMG
YQKGEYKFLH PNNDVNLSQS TNDAYPTALR VALYEKLGEL SESMKIIQNS FAKKAASFKD
VIKMGRTQLQ DAVPMTLEQE FRTYAVMIGE DIQRVHEARQ LVREINMGAT AIGTGINAHP
NYAKTVEAKL QEVTGRPFVT AGDLIEATQD TGAYVQISGV LKRVATKMSK ICNDLRLLSS
GPRTGFGEIN LPAMQPGSSI MPGKVNPVIP EVVNQVCFQV IGTDIAVTMA CEGGQLQLNV
FEPLIGYNLF NSINMMKNAF EALAYTCVDG ITANPERCKA LVLNSIGLVT ALNPFIGYEN
STMVAKEALE SGRSVYDIVL EKGLLDKAEL DDIIQPENMI KPRNFGLSEK SKFVKL
//
