ID I3Y151_ECOLX Unreviewed; 218 AA.
AC I3Y151;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Intimin {ECO:0000256|ARBA:ARBA00017346};
DE AltName: Full=Attaching and effacing protein {ECO:0000256|ARBA:ARBA00029955};
DE Flags: Fragment;
GN Name=eae {ECO:0000313|EMBL:AFL69930.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AFL69930.1};
RN [1] {ECO:0000313|EMBL:AFL69930.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C1 {ECO:0000313|EMBL:AFL69930.1};
RA Lali Growther G., Niren Andrew S.;
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004203}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004203}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the intimin/invasin family.
CC {ECO:0000256|ARBA:ARBA00010116}.
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DR EMBL; JQ809332; AFL69930.1; -; Genomic_DNA.
DR AlphaFoldDB; I3Y151; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR003344; Big_1_dom.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013117; Intimin_C.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR045197; NUP210-like.
DR PANTHER; PTHR23019:SF0; NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210; 1.
DR PANTHER; PTHR23019; NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED; 1.
DR Pfam; PF02369; Big_1; 1.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF07979; Intimin_C; 1.
DR SMART; SM00634; BID_1; 1.
DR SMART; SM00635; BID_2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2.
DR PROSITE; PS51127; BIG1; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 1..82
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFL69930.1"
FT NON_TER 218
FT /evidence="ECO:0000313|EMBL:AFL69930.1"
SQ SEQUENCE 218 AA; 23070 MW; E61FAA0A92EABB0F CRC64;
KEKNRSDAIT YTVRVMKEGA PVVDQKVTFS KDFGTLNKTE ATTDQNGYAT VKLSSNTPGK
AIVSAKVSGV GTEVKATTVE FFAPLSIDGD KVTVIGTGIT GALPKKWLQY GQVKLQATGG
NGKYTWKSSN TKIASVDNSG VITLNEKGSA TITVVSGDNQ SATYTINAPG SIVIAVDKNT
RVTYFDAENK CKTNSANLAQ SKELLANIYS TWGAAKKI
//
