ID I3Y2X4_MACFA Unreviewed; 229 AA.
AC I3Y2X4;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=MHC class II protein {ECO:0000313|EMBL:AFL70575.1};
DE Flags: Fragment;
GN Name=Mafa-DQA {ECO:0000313|EMBL:AFL70575.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:AFL70575.1};
RN [1] {ECO:0000313|EMBL:AFL70575.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23793105;
RA Xiang R., Zhang H., Deng Q., Yue R., Tang H., Zhang Y., Ling F., Zhuo M.,
RA Du H., Xu S., Xu Q., Wang X.;
RT "Comprehensive identification of high-frequency and co-occurring Mafa-DPA1,
RT Mafa-DQA1, Mafa-DRA, and Mafa-DOA alleles in Vietnamese cynomolgus
RT macaques.";
RL Immunogenetics 65:667-674(2013).
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ698487; AFL70575.1; -; Genomic_DNA.
DR AlphaFoldDB; I3Y2X4; -.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR CDD; cd21008; IgC1_MHC_II_alpha_HLA-DQ; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..192
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFL70575.1"
FT NON_TER 229
FT /evidence="ECO:0000313|EMBL:AFL70575.1"
SQ SEQUENCE 229 AA; 25295 MW; 44E0A2331315B65B CRC64;
GGEDIVADHV ASCGVNLYQT YGLSGQYTHE FDGDERFYVD LERKETAWRW PELSKFGGFD
PQGALRNLAV LKHTLNIVTK RYNSTAATNE VPEVTVFSKS PVMLGQPNTL ICLVDNIFPP
VVNITWLSNG RSVTEGVSET SFLPKSDHSF FKISYLTFLP SADEIYDCKV EHWGLDELLL
KHREPEIPAP LSELTETVVR ALGLSVGLVG IVVGTVLIIR GLRSVGASR
//
