ID I3Z6K9_BELBD Unreviewed; 505 AA.
AC I3Z6K9;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Belba_2314 {ECO:0000313|EMBL:AFL84877.1};
OS Belliella baltica (strain DSM 15883 / CIP 108006 / LMG 21964 / BA134).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Belliella.
OX NCBI_TaxID=866536 {ECO:0000313|EMBL:AFL84877.1, ECO:0000313|Proteomes:UP000006050};
RN [1] {ECO:0000313|Proteomes:UP000006050}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15883 / CIP 108006 / LMG 21964 / BA134
RC {ECO:0000313|Proteomes:UP000006050};
RA Lucas S., Copeland A., Lapidus A., Goodwin L., Pitluck S., Peters L.,
RA Mikhailova N., Davenport K., Kyrpides N., Mavromatis K., Pagani I.,
RA Ivanova N., Ovchinnikova G., Zeytun A., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Tindall B., Pomrenke H., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Belliella baltica DSM 15883.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP003281; AFL84877.1; -; Genomic_DNA.
DR RefSeq; WP_014772836.1; NC_018010.1.
DR AlphaFoldDB; I3Z6K9; -.
DR STRING; 866536.Belba_2314; -.
DR REBASE; 49024; M.Bba15883ORF2314P.
DR KEGG; bbd:Belba_2314; -.
DR PATRIC; fig|866536.3.peg.2378; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_018284_2_0_10; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000006050; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFL84877.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006050};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFL84877.1}.
FT DOMAIN 7..126
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 136..434
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 505 AA; 57219 MW; CDEEEA3E21CBFD6A CRC64;
MTESALISKV WNFANVLRDD GVGYGDYLEQ ITYLLFLKMA DEMSKPPYSK NIQFPRIKDT
EGKEIPDGDY CNWETLSKKR GAELEAYYAQ MLRSLGTERG ILGQIFTKSQ NKIQDPAKLL
RVIDMIAKEN WTLVGADIKG DIYEGLLEKN AADTKSGAGQ YFTPRALIRA MVECLAPKPG
KTIHDPSCGT GGFFLAAYDY ITSHHQLDRD QKHFLKNSTF SGNEIVASTR RLCLMNMFLH
SIGEIDGDTF ISPNDALIAD EGFRVDYVLA NPPFGKKSSM TITNEEGEQE KQDLSYNRQD
FWASTSNKQL NFLQHIRTLL KVNGEAAVVL PDNVLFEGGA GETVRKELLK TTELHTILRL
PTGIFYANGV KANVLFFDNK PASKEAWTKE VWIFDYRTNI HHTLKKGTMK LEDLEDFIKC
YNPSNRNKRT ETYSDSSPDG RWRKFSYEEI IARDKTNLDI FWLKDKSLAD LDNLPDPDVL
AEEIIEDVEA ALDGFRGIMG ILNKA
//
