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Database: UniProt
Entry: I3ZXU8_ORNRL
LinkDB: I3ZXU8_ORNRL
Original site: I3ZXU8_ORNRL 
ID   I3ZXU8_ORNRL            Unreviewed;       580 AA.
AC   I3ZXU8;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase {ECO:0000313|EMBL:AFL96532.1};
DE            EC=1.2.5.1 {ECO:0000313|EMBL:AFL96532.1};
GN   OrderedLocusNames=Ornrh_0314 {ECO:0000313|EMBL:AFL96532.1};
OS   Ornithobacterium rhinotracheale (strain ATCC 51463 / DSM 15997 / CCUG 23171
OS   / CIP 104009 / LMG 9086).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Ornithobacterium.
OX   NCBI_TaxID=867902 {ECO:0000313|EMBL:AFL96532.1, ECO:0000313|Proteomes:UP000006051};
RN   [1] {ECO:0000313|EMBL:AFL96532.1, ECO:0000313|Proteomes:UP000006051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51463 / DSM 15997 / CCUG 23171 / LMG 9086
RC   {ECO:0000313|Proteomes:UP000006051};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Goodwin L., Pitluck S., Peters L.,
RA   Mikhailova N., Teshima H., Kyrpides N., Mavromatis K., Pagani I.,
RA   Ivanova N., Ovchinnikova G., Zeytun A., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Lang E., Kopitz M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Ornithobacterium rhinotracheale DSM 15997.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP003283; AFL96532.1; -; Genomic_DNA.
DR   RefSeq; WP_014790162.1; NC_018016.1.
DR   AlphaFoldDB; I3ZXU8; -.
DR   SMR; I3ZXU8; -.
DR   STRING; 867902.Ornrh_0314; -.
DR   GeneID; 71568590; -.
DR   KEGG; orh:Ornrh_0314; -.
DR   PATRIC; fig|867902.3.peg.315; -.
DR   eggNOG; COG0028; Bacteria.
DR   HOGENOM; CLU_013748_3_0_10; -.
DR   OMA; YEATHEC; -.
DR   Proteomes; UP000006051; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0052737; F:pyruvate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:AFL96532.1};
KW   Oxidoreductase {ECO:0000313|EMBL:AFL96532.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006051};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          4..114
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          191..319
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          382..528
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   580 AA;  63681 MW;  F8D639D6FAA2083D CRC64;
     MAKRVADQLV EMLVEAGVKR VYGITGDSLN PVNDAIRNDG RLEWVHVRHE EAGAYAASMD
     AELNGIGCCM GSSGPGHVHL INGLYDANRA GNPVIAIAST CPSNKFGQEY FQETNPFYLF
     QDCSKYVYVA NTPTQFPHMM QHAIQAAIEQ KGVAVVGLPG DVAAAEANDI ITSQKNYKTE
     SVYLPSDAQL DTLAELLNQN KKISLYCGHG CRHAVPEVMA LAEKLKAPMA YSFRGKIFFD
     RVDNPYATGL NGLLGHRSGY LTCNDADVLV MLGTDFPYAE FLPQKIKIVQ IDEKPSRIGR
     RAKVDIGLAG DIKDTINALL PKLKGNDSDE FLKKMQKEYK ESEDALERFV KEDSTKTDEI
     QPEYVAHVIN ELAEDDAIFT VDTGMTSVWA ARFIKGKRGR YLTGSFNHGS MANAMPMSIG
     AAGAAPHRQV VAMCGDGGIS MLLGDLATIM QYKLPIKIIV FNNRSLGMVK LEMQVAGYVD
     WQTDMVNPEF DKIGELMGMK GIAVHKTSEV ESAIKEAFEH DGPALVNIYT NPNSLAMPPH
     ITLQQMKGFT TSMFKKLAEG KFGDIEQSIS SNIKHLTELF
//
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