ID I4A984_DESDJ Unreviewed; 901 AA.
AC I4A984;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=FAD/FMN-dependent dehydrogenase {ECO:0000313|EMBL:AFM00519.1};
GN OrderedLocusNames=Desde_2173 {ECO:0000313|EMBL:AFM00519.1};
OS Desulfitobacterium dehalogenans (strain ATCC 51507 / DSM 9161 / JW/IU-DC1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfitobacterium.
OX NCBI_TaxID=756499 {ECO:0000313|EMBL:AFM00519.1, ECO:0000313|Proteomes:UP000006053};
RN [1] {ECO:0000313|Proteomes:UP000006053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51507 / DSM 9161 / JW/IU-DC1
RC {ECO:0000313|Proteomes:UP000006053};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kruse T.,
RA de Vos W.M., Smidt H., Woyke T.;
RT "Complete sequence of Desulfitobacterium dehalogenans ATCC 51507.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFM00519.1, ECO:0000313|Proteomes:UP000006053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51507 / DSM 9161 / JW/IU-DC1
RC {ECO:0000313|Proteomes:UP000006053};
RX PubMed=25512312; DOI=10.1128/JB.02370-14;
RA Kruse T., van de Pas B.A., Atteia A., Krab K., Hagen W.R., Goodwin L.,
RA Chain P., Boeren S., Maphosa F., Schraa G., de Vos W.M., van der Oost J.,
RA Smidt H., Stams A.J.;
RT "Genomic, proteomic, and biochemical analysis of the organohalide
RT respiratory pathway in Desulfitobacterium dehalogenans.";
RL J. Bacteriol. 197:893-904(2015).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP003348; AFM00519.1; -; Genomic_DNA.
DR RefSeq; WP_014794005.1; NC_018017.1.
DR AlphaFoldDB; I4A984; -.
DR STRING; 756499.Desde_2173; -.
DR KEGG; ddh:Desde_2173; -.
DR eggNOG; COG0247; Bacteria.
DR eggNOG; COG0277; Bacteria.
DR HOGENOM; CLU_011400_0_0_9; -.
DR OrthoDB; 9794954at2; -.
DR Proteomes; UP000006053; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF103; GLYCOLATE OXIDASE SUBUNIT GLCE; 1.
DR Pfam; PF02754; CCG; 2.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}.
FT DOMAIN 46..216
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 901 AA; 100109 MW; B060D0CC9932C6F1 CRC64;
MKNNLTTGQM NKIQRLLGDR ARFDKIERLV YSHDMGIMPE QIRSLIRCLP DAVVQPINVD
EIIEIVKMAQ TEKIPIVPRG AASAGFGGSV PAKGGIVLDL VRMNKVLEID NKKGTATVEP
GVIWSNLESE LVKQGQTLRT YPSSSNSSTV GGWVAQGGCG YGGYEYGECG ENIVSVDVVL
PTGELKTFAG EEIANVYGLC GTTGIIVKVI VKLREIDEER VMLSSFPDLK SAADFLTNLS
KAKVPVWNVG FSTPSFTALK QKAQEHYSLP EDEYLVTIVF PKHRRSAAEK QVKELTAKHG
GNVMRDKLAE EEWREKFYPM RFKKLGPTFV ASEVVLPIGK LAQFVSEVEE KYKGEFAMEG
TMVGVGEISL LGFMLTDERK LGFPLAYACA LDVIDAAEKM GGRVFTLGMY FTDRAKSFYG
QKELERIWEY KQSIDAEGIM NPGKVIPPSL DKQSPIKMLS GAMKIANAGS GVIGLAGRLL
TKWQKGEFSS PLEEDLTDDT FACAMCGYCR NICTVFDAVP WESNSPRGKY FILNQYIKGK
IKLDDEVGRA LYPCTTCKKC DTVCQVRSHN AHHWMSLRYE FSKNKLHNTG LEIIRNNVLN
IGNFWGVPGN ERLNWLDVPV QTHGKLAYWS GCWASTIMDT MAQNSTRILN ALEIPFVHYG
EKEQCCGLYL SLGGYKEDFQ TIVRRNLNMF NESGVDTILF SCPGCYATFN ENYRQIAMEL
GLECTIRFKH IAVYLSELIG EGRLKFKVPV HSTVTYHDSC HVGRWFGHYD EPRNVLRAIP
GLELREMEHI KEQGLCCGLV SAFDSLASVS HSGMKRVQEA ENTKAEWLVT NCAGCGSQFN
ATCHAMGTKV QQADLTELVS KALGIPAEDP SEKVGAYMVQ CVEMLKDSVL TPIVVPAEVR
K
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