ID I4ABR8_DESDJ Unreviewed; 262 AA.
AC I4ABR8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538, ECO:0000256|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000256|HAMAP-Rule:MF_00621};
GN OrderedLocusNames=Desde_3111 {ECO:0000313|EMBL:AFM01403.1};
OS Desulfitobacterium dehalogenans (strain ATCC 51507 / DSM 9161 / JW/IU-DC1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfitobacterium.
OX NCBI_TaxID=756499 {ECO:0000313|EMBL:AFM01403.1, ECO:0000313|Proteomes:UP000006053};
RN [1] {ECO:0000313|Proteomes:UP000006053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51507 / DSM 9161 / JW/IU-DC1
RC {ECO:0000313|Proteomes:UP000006053};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kruse T.,
RA de Vos W.M., Smidt H., Woyke T.;
RT "Complete sequence of Desulfitobacterium dehalogenans ATCC 51507.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFM01403.1, ECO:0000313|Proteomes:UP000006053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51507 / DSM 9161 / JW/IU-DC1
RC {ECO:0000313|Proteomes:UP000006053};
RX PubMed=25512312; DOI=10.1128/JB.02370-14;
RA Kruse T., van de Pas B.A., Atteia A., Krab K., Hagen W.R., Goodwin L.,
RA Chain P., Boeren S., Maphosa F., Schraa G., de Vos W.M., van der Oost J.,
RA Smidt H., Stams A.J.;
RT "Genomic, proteomic, and biochemical analysis of the organohalide
RT respiratory pathway in Desulfitobacterium dehalogenans.";
RL J. Bacteriol. 197:893-904(2015).
CC -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC involved in the adaptive response to starvation and acts by directly or
CC indirectly controlling the expression of numerous genes in response to
CC nutrient availability. During rapid exponential growth, CodY is highly
CC active and represses genes whose products allow adaptation to nutrient
CC depletion. {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000256|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP003348; AFM01403.1; -; Genomic_DNA.
DR RefSeq; WP_014794883.1; NC_018017.1.
DR AlphaFoldDB; I4ABR8; -.
DR STRING; 756499.Desde_3111; -.
DR KEGG; ddh:Desde_3111; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OrthoDB; 2056at2; -.
DR Proteomes; UP000006053; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02787; codY_Gpos; 1.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00621};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00621}.
FT DOMAIN 3..180
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 200..256
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
FT DNA_BIND 205..224
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT REGION 1..157
FT /note="GAF domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
SQ SEQUENCE 262 AA; 28848 MW; 952E64BD25CFE958 CRC64;
MKNLLEKTRG ISKLIQKAAG HPVDFDEMAN VLSESIQSNC YIVGRRGKIL GYSFMPNFGC
NTMEDIVVHT ERFPESYNEG LLKVTETRSN TTQVANGCVF NEKERCHFNN KITTIVPILG
GGERVGTLVL AKFDQDFSEA DLILAEYGAT VVGMEILRIK AERAEEEARK KAAVQIAVGT
LSYSELEAVE HIFAELGGGD GLLVASKIAD RVGITRSVIV NALRKFESAG VIESKSLGMK
GTYIRVLNDY LLEELDKISH NK
//
