ID I4BRM0_MYCCN Unreviewed; 599 AA.
AC I4BRM0;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase {ECO:0000313|EMBL:AFM19927.1};
DE Flags: Precursor;
GN OrderedLocusNames=Mycch_5242 {ECO:0000313|EMBL:AFM19927.1};
OS Mycolicibacterium chubuense (strain NBB4) (Mycobacterium chubuense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=710421 {ECO:0000313|EMBL:AFM19927.1, ECO:0000313|Proteomes:UP000006057};
RN [1] {ECO:0000313|EMBL:AFM19927.1, ECO:0000313|Proteomes:UP000006057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBB4 {ECO:0000313|EMBL:AFM19927.1,
RC ECO:0000313|Proteomes:UP000006057};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T.,
RA Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium chubuense NBB4.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP003053; AFM19927.1; -; Genomic_DNA.
DR RefSeq; WP_014818392.1; NC_018027.1.
DR AlphaFoldDB; I4BRM0; -.
DR STRING; 710421.Mycch_5242; -.
DR KEGG; mcb:Mycch_5242; -.
DR PATRIC; fig|710421.3.peg.5227; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_0_11; -.
DR OrthoDB; 4959782at2; -.
DR Proteomes; UP000006057; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:AFM19927.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006057};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..120
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 199..328
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 388..543
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 599 AA; 65570 MW; F417AABB1224DAD1 CRC64;
MSDTVGDVLL ARLREWGVKQ VFGFPGDGIN GLLAAWQRAD DKPQFVQARH EEMSAFEAVG
FAKFSGQVGV CVATSGPGAV HLLNGLYDAK LDHVPVVAIV GQTERSAMGG SYQQEIDLIS
LYKDVCSEYV QMCTVPKQLP NLIDRAIRIA LSEGAPTAII VPSDVFELPY EPPEHAFKQV
PSSLGMAEAK VVPDDDALRR TADLLNSGHK VAMLVGQGAR GCVAELTEVA ELLGAGAAKA
LLGKDVLPDD LPWVTGSIGL LGTTASWHLM MDCDTLLTVG SNFPYTQFLP KLDQARAVQI
DRSGKWIGMR YPYEINLVGD AKSTLQALIP LLERKTDRSW RDKIEKWVVS WWTTVQRRAM
TDADPVNPMR IFWELSERMP HNAIIAADSG SSANWYARHL KFRGDVRGSL SGTLATMGPG
VPYVIGAKWA HPDRPTIAFV GDGAMQMNGL NELITISKYW KQWTDPRLII AILHNNDLNQ
VTWEMRAMEN SPKFEASQSL PDVDYANFAR SLGLHGDNID DAAALGDAWD RALAADRPTV
LDVRCDPDVP PIPPHATFDQ AKSLVEAVVG GDADSAGFIK QGIKQKVQQY FPSEKKDRS
//
