UniProt: I4BSE6

Database: UniProt
Entry: I4BSE6_MYCCN

LinkDB:  I4BSE6_MYCCN 
Original site:  I4BSE6_MYCCN

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (5)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (1)   
All databases (11)   

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ID   I4BSE6_MYCCN            Unreviewed;       556 AA.
AC   I4BSE6;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Type VII secretion-associated serine protease mycosin {ECO:0000313|EMBL:AFM20203.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Mycch_5538 {ECO:0000313|EMBL:AFM20203.1};
OS   Mycolicibacterium chubuense (strain NBB4) (Mycobacterium chubuense).
OG   Plasmid pMYCCH.01 {ECO:0000313|EMBL:AFM20203.1,
OG   ECO:0000313|Proteomes:UP000006057}.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=710421 {ECO:0000313|EMBL:AFM20203.1, ECO:0000313|Proteomes:UP000006057};
RN   [1] {ECO:0000313|EMBL:AFM20203.1, ECO:0000313|Proteomes:UP000006057}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBB4 {ECO:0000313|EMBL:AFM20203.1,
RC   ECO:0000313|Proteomes:UP000006057};
RC   PLASMID=pMYCCH.01 {ECO:0000313|EMBL:AFM20203.1,
RC   ECO:0000313|Proteomes:UP000006057};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T.,
RA   Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT   "Complete sequence of plasmid 1 of Mycobacterium chubuense NBB4.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR   EMBL; CP003054; AFM20203.1; -; Genomic_DNA.
DR   RefSeq; WP_014805492.1; NC_018022.1.
DR   AlphaFoldDB; I4BSE6; -.
DR   MEROPS; S08.131; -.
DR   KEGG; mcb:Mycch_5538; -.
DR   PATRIC; fig|710421.3.peg.5523; -.
DR   HOGENOM; CLU_011263_13_1_11; -.
DR   Proteomes; UP000006057; Plasmid pMYCCH.01.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00306; Peptidases_S8_S53; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023834; T7SS_pept_S8A_mycosin.
DR   NCBIfam; TIGR03921; T7SS_mycosin; 1.
DR   PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR01217; PRICHEXTENSN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW   Plasmid {ECO:0000313|EMBL:AFM20203.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000006057};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           34..556
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003686922"
FT   TRANSMEM        529..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          245..485
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          152..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..241
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        103
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        136
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        438
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   556 AA;  56034 MW;  E08D1890AAD447B1 CRC64;
     MSRSAFGARA RVGAALVGTV ALLAATSVGA SWAVTPPVVP PGPPPADPAP GPDWPMKQTR
     ACTLTGVMPG SDLREMPPAL PLLDMPAVWQ ESTGAGVVVA VIDTGVAPSP RLPHLVAGGD
     YVMGQYGDGL ADCDAHGTLV ASLIGAAPSG APLPVRPEGA QVAPPPPAAP APEPVPPPPP
     PPTITITKTT AAPPPPPPPP AEPPPPPPGE LPPGPPPAWG PSGPVAEAPR LPAPQLPPPT
     GGPDGLIGIA PDAVILAIRQ SSQNFGLKDP RLDQDMEQTR RTGDINSLAR AIVHAANLGA
     RVINISLVSC IPVTKPTDQT VLGAALRYAA VDRDAVIVAA AGNAGTQGCT QNPQPPTGAS
     GWDDVTTIAS PAWFDDYVVA VSATDNFGAP LMGQAASLHG PWVDLAAPGA DIVGLSTSGS
     VINASIDDDK FKPIIGSSFS AAYVSGVAAL VRAKFPQLSA AEVIHRLTAT AHAPAGGRDN
     VIGYGVVDPL AALTWDVPPA PAKAPTATDV PLHVPPPPPP ADPRPVRVLA AQIGAGVVLV
     GAVLWGTTVW RKKKQR
//

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