ID I4C0S4_DESTA Unreviewed; 403 AA.
AC I4C0S4;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=RND family efflux transporter, MFP subunit {ECO:0000313|EMBL:AFM23165.1};
GN OrderedLocusNames=Desti_0430 {ECO:0000313|EMBL:AFM23165.1};
OS Desulfomonile tiedjei (strain ATCC 49306 / DSM 6799 / DCB-1).
OC Bacteria; Thermodesulfobacteriota; Desulfomonilia; Desulfomonilales;
OC Desulfomonilaceae; Desulfomonile.
OX NCBI_TaxID=706587 {ECO:0000313|EMBL:AFM23165.1, ECO:0000313|Proteomes:UP000006055};
RN [1] {ECO:0000313|Proteomes:UP000006055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49306 / DSM 6799 / DCB-1
RC {ECO:0000313|Proteomes:UP000006055};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Zeytun A.,
RA Lu M., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "Complete sequence of chromosome of Desulfomonile tiedjei DSM 6799.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP003360; AFM23165.1; -; Genomic_DNA.
DR RefSeq; WP_014808324.1; NC_018025.1.
DR AlphaFoldDB; I4C0S4; -.
DR STRING; 706587.Desti_0430; -.
DR KEGG; dti:Desti_0430; -.
DR PATRIC; fig|706587.4.peg.490; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_7; -.
DR OrthoDB; 9772050at2; -.
DR Proteomes; UP000006055; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000006055};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 41..364
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 68..297
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 403 AA; 43779 MW; 135C9F4A855CAFB4 CRC64;
MQSNETVYEP LKWIVVFTAL LGGLFLGGCD RRQQSQQPAV PEVATVTVQP QELVLTTELP
GRTCAYLVAE IRPQVNGIIK DRLFTEGSDV KAGQILYQID PAPFQAALDS ARASLLKSEA
NLPAVRLKAE RSKQLLEAKA VSQQDFDDKD AALKQAEADV AYWKAAVETA RINLDYTHIC
APISGRIGKS NVTTGALVTA HQAVPMATIQ EIDPIYVDVA QSTTELLRLK RNFQRGLLKN
NGENQRTVKL LLDDGRPYPL EGTLQFRDVT VDPTTGSVIL RIVFSNPKHV LLPGMFVRAT
VVEGTADQAI LVPQQGVSRD PKGNPIALIV DADGKVQQKK LKLDRPIGDK WLVSSGLAPG
DNLIVEGSLK VRPGATVKSV PFLDGQKAVK TPEDTHTASK ESN
//
