ID I4CJR0_HBV Unreviewed; 674 AA.
AC I4CJR0;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AFM29859.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AFM29859.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AFM29859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y2-6 {ECO:0000313|EMBL:AFM29859.1};
RX PubMed=22675528; DOI=10.1371/journal.pone.0038241;
RA Zhou B., Wang Z., Yang J., Sun J., Li H., Tanaka Y., Mizokami M., Hou J.;
RT "Novel evidence of HBV recombination in family cluster infections in
RT Western china.";
RL PLoS ONE 7:E38241-E38241(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JX036326; AFM29859.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..431
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFM29859.1"
SQ SEQUENCE 674 AA; 74745 MW; 693B64FAD40E1C7D CRC64;
GSPYSWEQEL QHGRLVFQTS TRHGDESFCS QSSGILSRSP VGPCVWSQLK QSRLGLQPQQ
GSLARGKSGR SGSIRARVHP TTRRSFGVEP SGSGHINNSA SSTSSCLHQS AVRKTAYSHL
STSKRQSSSG HAVEFHNIPP SSARSQSKGP IFSCWWLQLR NSKPCSDYCL THIVNLLEDW
GPCTEHGEHN IRIPRTPARV TGGVFLVDKN PHNTTESRLV VDFSQFSRGS THVSWPKFAV
PNLQSLTNLL SSNLSWLSLD VSAAFYHIPL HPAAMPHLLV GSSGLPRYVA RLSSTSRNNN
YQYGTMQDLH DSCSRTLYVS LLLLYKTFGR KLHLYSHPII LGFRKIPMGV GLSTFLMAQF
TSAICSVVRR AFPHCLAFSY VDDVVLGAKS VQHLESLFTS ITNFLLSLGI HLNPNKTKRW
GYSLNFMGYV IGSWGTLPQE HIVLKIKQCF RKLPVNRPID WEVCQRIVGL LGFAAPFTQC
GYPALMPLYA CIQSKQAFTF SPTYKAFLCK QYLNLYPVAR QRSGLCQVFA DATPTGWGLA
IGHRRMRGTF VAPLPIHTAE LLAACFARSR SGAKLIGTDN SVVLSRKYTS FPWLLGCAAN
WILRGTSFVY VPSALNPADD PSRGRLGLYR PLLHQPFRPT TGRTSLYAVS PSVPSHLPDR
VHFASPLHVA WRPP
//
