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Entry: I4D872_DESAJ
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ID   I4D872_DESAJ            Unreviewed;       333 AA.
AC   I4D872;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   SubName: Full=ATPase involved in DNA replication initiation {ECO:0000313|EMBL:AFM41996.1};
GN   OrderedLocusNames=Desaci_3089 {ECO:0000313|EMBL:AFM41996.1};
OS   Desulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=646529 {ECO:0000313|EMBL:AFM41996.1, ECO:0000313|Proteomes:UP000002892};
RN   [1] {ECO:0000313|EMBL:AFM41996.1, ECO:0000313|Proteomes:UP000002892}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22704 / JCM 16185 / SJ4
RC   {ECO:0000313|Proteomes:UP000002892};
RX   PubMed=23105050; DOI=10.1128/JB.01392-12;
RA   Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA   Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA   Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R.,
RA   Land M.L., Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I.,
RA   Huntmann M., Wei C.L., Davenport K.W., Daligault H., Chain P.S.,
RA   Chen A., Mavromatis K., Markowitz V., Szeto E., Mikhailova N.,
RA   Pati A., Wagner M., Woyke T., Ollivier B., Klenk H.P., Spring S.,
RA   Loy A.;
RT   "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT   Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei
RT   DSM13257T, and Desulfosporosinus acidiphilus DSM22704T.";
RL   J. Bacteriol. 194:6300-6301(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP003639; AFM41996.1; -; Genomic_DNA.
DR   RefSeq; WP_014827987.1; NC_018068.1.
DR   EnsemblBacteria; AFM41996; AFM41996; Desaci_3089.
DR   KEGG; dai:Desaci_3089; -.
DR   KO; K02313; -.
DR   OMA; HTYEALF; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DACI646529:GLCJ-2947-MONOMER; -.
DR   Proteomes; UP000002892; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002892};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002892}.
FT   DOMAIN       24    153       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      230    298       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   333 AA;  38598 MW;  D69D15ED4673A5E0 CRC64;
     MNWFLSDFNI KAWRFINHYE PATAPSMTLV YGPAGVGKSS LLKHVEQTWK NEGSLLIDAA
     SFSRQYAFAS QENRLLQFRR SYRAVPLLLL DDLQGLAGKK QTIEEIHYTY EYILQNGGKM
     MAVVETELLN LTFLGERLMS RLLSGVVIPL ARPQEYEIEA FIEEYSHRLL LSMDSAIPEF
     IARQTTSLAE AKKVLRQFID YAELYNDELS VQCFLSYWRE QARKQSQEKS PMNILRVTAQ
     ITGHTPEELV GPAQKPSINE ARQLAIYTVR MLCKLSYPEI AVYFNRRHTT IIAAYKKMQE
     KLLQDQALFR RYQEITGKFK EDHKKSFGNM SRP
//
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