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Database: UniProt
Entry: I4EF75_9CHLR
LinkDB: I4EF75_9CHLR
Original site: I4EF75_9CHLR 
ID   I4EF75_9CHLR            Unreviewed;       465 AA.
AC   I4EF75;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCF83337.1};
GN   ORFNames=NITHO_2220003 {ECO:0000313|EMBL:CCF83337.1};
OS   Nitrolancea hollandica Lb.
OC   Bacteria; Chloroflexi; Sphaerobacteridae; Sphaerobacterales;
OC   Sphaerobacterineae; Sphaerobacteraceae; Nitrolancea.
OX   NCBI_TaxID=1129897 {ECO:0000313|EMBL:CCF83337.1, ECO:0000313|Proteomes:UP000004221};
RN   [1] {ECO:0000313|EMBL:CCF83337.1, ECO:0000313|Proteomes:UP000004221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=none {ECO:0000313|Proteomes:UP000004221};
RX   PubMed=22763649; DOI=10.1038/ismej.2012.70;
RA   Sorokin D.Y., Lucker S., Vejmelkova D., Kostrikina N.A.,
RA   Kleerebezem R., Rijpstra W.I., Damste J.S., Le Paslier D., Muyzer G.,
RA   Wagner M., van Loosdrecht M.C., Daims H.;
RT   "Nitrification expanded: discovery, physiology and genomics of a
RT   nitrite-oxidizing bacterium from the phylum Chloroflexi.";
RL   ISME J. 6:2245-2256(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCF83337.1}.
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DR   EMBL; CAGS01000138; CCF83337.1; -; Genomic_DNA.
DR   RefSeq; WP_008476404.1; NZ_CAGS01000138.1.
DR   EnsemblBacteria; CCF83337; CCF83337; NITHO_2220003.
DR   Proteomes; UP000004221; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004221};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004221}.
FT   DOMAIN      158    286       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      370    439       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     166    173       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   465 AA;  51739 MW;  2B4331193083882D CRC64;
     MQGKQIWQAA LGDLETRVSR ANFETWLRST QIIELRDDLA KIGAPNSFAA DQLRSKFAPD
     IQEALSLIVG HRVAVEFAVL NSSQTGTPGT QRTTRPTGRK AASKSATPEH APAQQLELTG
     APEHGLNPKY VFEKFVVGSN NRLAHAAALA VADRPAEKFN PLFLYGGVGL GKTHLLHAIG
     HRALARNPNL KIRYVSSETF TNDMVNAIRH QRNEEFRNRY RTIDILMIDD IQFIAGKEGT
     QEEFFHTFNA LYQSGKQIVI SSDRPPKAIA TLEDRLRSRF EGGLLADVQP PDLETREAIL
     AEKGQDLGVL MPADVLEYVA QKVQLNIREL EGALNKIIAL ANLYGQPISM NLAVQALTDS
     ALETRRRQLT PEHVLDAVTR YYRVTPVDLR GPVRRRDVVI PRQVAMFLMR AETGSSLVEI
     GQRLGGRDHS TVLHGIEKVE RQIETDQRLR SEIIAVKELL YSGGA
//
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