ID I4EUW5_9ACTN Unreviewed; 878 AA.
AC I4EUW5;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=ComEC/Rec2-related protein (Modular protein) {ECO:0000313|EMBL:CCH87178.1};
GN OrderedLocusNames=MODMU_1739 {ECO:0000313|EMBL:CCH87178.1};
OS Modestobacter marinus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH87178.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH87178.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC501 {ECO:0000313|EMBL:CCH87178.1,
RC ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FO203431; CCH87178.1; -; Genomic_DNA.
DR AlphaFoldDB; I4EUW5; -.
DR STRING; 477641.MODMU_1739; -.
DR KEGG; mmar:MODMU_1739; -.
DR PATRIC; fig|477641.3.peg.1637; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_4_0_11; -.
DR OMA; RTDKQGA; -.
DR OrthoDB; 7177610at2; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 544..738
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 793..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 87724 MW; F158077554F5747E CRC64;
MTAPRSGPPV RRVRSRERWS WVDLRLVPPA GTVWAGTLAA RGLPAGPSLA VAAGAAVAAG
LLLLRTARGR SGPAGAVAVG CLAALTVVGA VAAVRAEART ASPLPGLAAR AAVVPVVVEL
DDDPRPLTGA GEPRVLVPAT ATEVDGHRTG GDPVLVFGPA DQWTGLLPGQ SVRLRVAVRA
AEPGDDVLAV LSARSAPSRL AGPGAVQTAA GALRAGLARS AERTLPGRPA GLLPGLVVGD
TSGMDPALTA EFRRAGLSHL TAVSGANVAI VVALVLWPLR ARGADRRVQA AVGVLAVVGF
VVLARPGASV LRAAVMGGVA LLALASGRPR AAVPALAASV VLLLLVEPAL ATDAGFALSV
AATAGIVLLA PSWSRALRGH RFPRPVADAV AVSAAAGLVT APLVAALSGV VSVVSLPANL
LAAPAVAPAT VLGLLAALVS PVLPAGADAL SWLAGWPVRW LVLVAEQAAA VPDGATGWAG
GAPGAVLLAA LIGGAAWALL RWPRLRWVAL AALVGALLLG WPLRQVNRGW PLADTVVVAC
DVGQGDALVV PTGPGEAVLV DAGPDGALVA GCLDRLGVQR LPLVLLSHLD ADHVAGLAGA
LAGRQVDEVA TGALTPTDER VPALERVVAA AGARHVVLAP GERRTVGAAA VEVLAPDPAR
AVAGAEPNDL SMVARVTVRG LRVLLTGDLG AEAEARLVTA GTDLSADVLK VPHHGSADAD
PGFLAASGAV VALVSVGADN SYGHPADRLL DLLAADGMRT YRTDRDGDVA VVGRAGEWGV
AVRGPDVVQR ATAAGAPGVP AGTPAGPAAA RSRRHRVAAW PRGTQRSSTA RTDVAAAHRG
RRGGAAPGPR RVRGPGRGAR AARRQRGARA GRGRPPDR
//
