ID I4H1K3_MICAE Unreviewed; 889 AA.
AC I4H1K3;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=MICAE_70004 {ECO:0000313|EMBL:CCI15927.1};
OS Microcystis aeruginosa PCC 9806.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=1160282 {ECO:0000313|EMBL:CCI15927.1, ECO:0000313|Proteomes:UP000003273};
RN [1] {ECO:0000313|EMBL:CCI15927.1, ECO:0000313|Proteomes:UP000003273}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9806 {ECO:0000313|EMBL:CCI15927.1,
RC ECO:0000313|Proteomes:UP000003273};
RA Genoscope - CEA;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI15927.1}.
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DR EMBL; CAIL01000278; CCI15927.1; -; Genomic_DNA.
DR RefSeq; WP_002779972.1; NZ_HE973220.1.
DR AlphaFoldDB; I4H1K3; -.
DR REBASE; 316509; M.Mae9806ORF70004P.
DR HOGENOM; CLU_013049_4_0_3; -.
DR Proteomes; UP000003273; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:InterPro.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..161
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 177..481
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 645..672
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..802
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 889 AA; 101937 MW; 134A5BA7737C0DF4 CRC64;
MKQEKITLSQ LEGFLFKAAD ILRGKMDASE FKEFIFGMLF LKRLSDEFER KQAQLKKQYA
HIPDPSLLAE LLESETSYGE TFFVPPRARW HQSWRDENGQ EVPPLKHLKQ DIGNMLNKAL
AAVEDANDAL AGVLKNNIDF NATKGKTKIP DQKWKDLLDH FNQPQFVLVN DNFEFPDLLG
AAYEYLIKYF ADSAGKKGGE FYTPAEVVRL LVQLVKPQAG HTIYDPTVGS GGFLIQSYQY
VEEQGQNPQN LALYGQDSNG TVWSICNMNM ILHNITRFTI ENGDTLEDPL ILENGQIRKF
DRVLANPPFS QDYSRANLKF TNRFREFCPE KGKKADLMFV QHMIASLKPD GHMATIMPHG
VLFRGGKEKL IREILIEDDL IEAIISLPPG LFYGTGIPAC VLVVNKNKPD ELRDKILFIN
ADREYAEGKN QNKLRPEDIE KIDYVFTHKR EYPKYSRLVD KSEIVEKHDF NLNIRRYVDN
TPDPEPEDVK AHLMGGIPQA EIAAQQDTFA KFGINTNTLF RPLRPGYASF CPEIATKAAI
KENLEANPDL QARISDHYTT LKNWWREARD DFAKLEGNNI MPQVRQQLLS SLKQQLIPLG
VLDEFKSAGV FVNWWQQIRY DLKTIINTGW HHTLIPDQYL LAAFFQAEEA AIEELESKIS
AVQGELSEAV ESAQEVANYE PEEEETVSAA SIKKWLKELI DDLKQSQGDS AARERQSYQQ
EYNVITDIEN RIKLLKNTLK EQQSQLELKL RLKRVGDEEF KAETIELLEQ VQNQLMGLNA
SKKEEKAKIN ALNKDKKALE IKLSYPEGLL TEIGGQLRDE EAKKLILKKL YDWVSEQLTR
YLNGEKRGLV AKVENLWDKY AVSSQEMEAQ REQTLGELNE FLVKLGYRE
//