ID I4H3D5_MICAE Unreviewed; 2651 AA.
AC I4H3D5;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Similar to tr|Q9RAH4|Q9RAH4 {ECO:0000313|EMBL:CCI16559.1};
GN ORFNames=MICAF_2050001 {ECO:0000313|EMBL:CCI16559.1};
OS Microcystis aeruginosa PCC 9807.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=1160283 {ECO:0000313|EMBL:CCI16559.1, ECO:0000313|Proteomes:UP000003613};
RN [1] {ECO:0000313|EMBL:CCI16559.1, ECO:0000313|Proteomes:UP000003613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9807 {ECO:0000313|EMBL:CCI16559.1,
RC ECO:0000313|Proteomes:UP000003613};
RA Genoscope - CEA;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI16559.1}.
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DR EMBL; CAIM01000119; CCI16559.1; -; Genomic_DNA.
DR HOGENOM; CLU_000022_11_0_3; -.
DR Proteomes; UP000003613; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..68
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1057..1132
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2556..2631
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT COILED 2263..2290
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2651 AA; 297355 MW; F8ACE1F3F6E4F443 CRC64;
MLVQIWTEIL KVEQVGIYDN FFEIGGHSLL ATQLVSRIRS LFKIELPLRS LFGAATVAEL
AHLIGQLQQQ NLTLTVPPIL PRTKDTELPL SFAQQRLWFL DQLQPNSALY NIPMVLHFRG
NFNQKALEQS LQEICDRHEI LRTNFVTIDG QPTQVIQPTR ETISVVDLQD FPIQEQAEKT
QQLKQKQATQ PFDLAKESLI RITLVVLSET EHLLLVCMHH IISDGWSIEV LIHELTSLYN
AYVQNQPANL APLPIQYGDF ALWQKQWLQG DVLQSQLNYW QNQLTAAPPL LSLPTDHPRP
AVQSFVGTQQ EFSLSPKLSQ ALTELSRQQG VTLFMTLLAA FDALLYRYTG SSDILVGTPI
ANRNRSEIEG LIGFFVNTLV MRTDVSDNPS FSQLLTRVRE VTMDAYAHQD LPFEMLVEAL
QPERDLSHTP LFQVAFVLQN TPKSEIAMTG LTVTDLPPEN ATAKFDLTLA MVNTDDGLKG
VWEYNTALFE SSTIERLSGH FLNLLGGIVA NPQAQISQLP LLTESETNQL LIEWNNTQVD
YPEYKCIHQL FEEQVKRTPD AVAVVYSEQQ LTYNELNCRA NQLAHYLQSL GVKPEQLVGI
CLERSLEMIV GLLAILKAGG AYVPLDPDYP SERLQFAIAD AQLSFLLTQE GLINKLPEHQ
ARLILLDRFT EEINQNSQDN LTGVVTANNL ANLIYTSGST GKPKGVMVEH RGLFNLAQAQ
IKTFNVQSNS RLLQFASLNF DASIWEIIMA MGAGATLYLD SKDALMPGLP LMGILKDYGI
THITLPPSAL AALPLEEIPE LQTIIVAGEA CSEELSKQWA RGRNFFNAYG PTETSVCATV
EKWTDETVKV TIGRPIANTQ VYILDSHLQP VPIGVVGELH IGGLGLARGY LNRPQLTQEK
FIPNPFEKDE VIPPTPLNKG GNKPSKLYKT GDLARYLPDG NIEYLGRIDN QVKIRGFRIE
LGEIEALLNQ NEAVQSSCVI VREDNPGDKR LVAYVVPQHE INLTINEIRQ FLRAKLPDYM
VPTAFILLDA FPLTPNGKID RRALPVPDLQ GKGEYIAPRN PIEEKMAQIW GEVLKLERVS
VEDNFFELGG HSLLATQVIS RLQETFEIVL PLRYLFESPT IAQLSGVILK ELQTGLGLKL
PSIVPVNRED DIPLSWAQER LWFVNQLEGE SGAYTIDLTM RLRGNLNIKA LEKAFQAIIQ
RHEPLRTQFK LKDNQPIQAI DPNVTFTLPV VNLQNLSHSE QQVKNLLLAA ASEPFDLESG
SVLRVKLWQL QTEEYVLLLA IHHIAADGWS IGVLVDELSV YYRSFCTGTK ADLPDLSIQY
ADFAVWQRQW LTNEVLDRQL SYWKQQLTRI PLLHQLPTDR PRPAIQSFRG GTERLQLDSQ
LTQQLKKLSQ ESGSTLFMTL LAGFAVLLSR YSQQTDVVIG SPIANRNRTE IEGLIGFFVN
TLVLRFDLSQ DPTFEDFLAQ VRQTTQDAYD HQDLPFEMLV EKLQIERHLD RNPLTQIVFA
LQNAPSSPWD LPGVNIEEIP SGLDSVRVDL EVYLWDAPEG LGGFCSYNRD LFDAETIVRM
MTHLKTLLAA IVENPRQSVA SLPLLNPEEE YQLLEGWNET KADYSYNKCI HQLIEEQAAR
TPEAVAVVFE NQQLTYAELN SQANQLADYL RSLGVETEVI VGLCVERSLD MIVALIGILK
AGAAYLPLDP EYPQERLQFM LEDSQVPLLL TQSSLIDKLP NHQAKTVFLA EIWQEIKPMN
RDNLTGKVTA SNLANVIYTS GSTGKPKGVM VEHQGLCNLA LAQIETFAVS SQSRVLQFAS
FSFDACISEV LMALGAGATL YLASKDNLMP GVPLIKQLRD NKITHITLPP SALAVLPWEN
LSSLQTIIVA GEACSPELMK KWSQGRNFFN GYGPTEGSVC ATVAKCTPVD EKITIGRPIP
HVQVYILDSH LQPVPIGVPG ELHIGGAGVA RGYLNRPELT AEKFISNPFV SLDPPLTPLD
KGGEQPSKLY KTGDLARYLP DGRIEYLGRI DNQVKVRGFR LELGEIEAVL SQHPLVQEAV
VIARADQKSD HDHDPLNTNL VAYLVPALKG QVLPEQLAQW QSEYVSDWQK IYEESYSKPQ
PQIEDPTFNI SGWNSSYTGQ AIPPAEMREW VDQTVSRILG NQPPQRVLEI GCGSGLLLFR
VAKHCQEYWG ADYSAATINN LEHLCSTIES LEGKVKLLHR TADDFTGIPQ ATFDRVVINS
VVQYFPSVDY LLQVIAGAVK AIADRGKIFL GDIRSLSLLE PYHAAVQLAR AEANKTLEQW
QKQVNQSVAT EEELLIEPQF FIALKQRFPR ISWVEIAPKR GQADNELTQF RYDVTLHLDT
DGQKTTIPWL NWQRDRVSVG QLQDKLKLEQ PEYLGIRDVP NQRLQKALQI LDCLENPPGV
KTVGELRQLL GKNTRIGINP EQMWQLGEQL GYTVHLSWWE GSQDGSFDVV FCRQNAILEP
IINKIDEKPY PNFWDDETII PKSWTDYTNN PLYGKLVQKL VPQVREFVQQ KLPSYMVPQA
FVLLNALPLT PNGKVDRQAL PTPDTATRNL ATGFLAPRTP IETQMSQIWS EVLGVERIGI
KDNFFELGGH SLLATQVISR SRDLFSVELS LQNLLEYPTI ANLAQIIEVL SVTPGETAMT
ESLEDYEDGE L
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