ID I4M1G6_GARVA Unreviewed; 337 AA.
AC I4M1G6;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=3'-5' exonuclease and CRISPR-associated Cas2 family protein {ECO:0000313|EMBL:EIK83056.1};
GN ORFNames=CGSMWGv1500E_02661 {ECO:0000313|EMBL:EIK83056.1};
OS Gardnerella vaginalis 1500E.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Gardnerella.
OX NCBI_TaxID=698957 {ECO:0000313|EMBL:EIK83056.1, ECO:0000313|Proteomes:UP000032875};
RN [1] {ECO:0000313|EMBL:EIK83056.1, ECO:0000313|Proteomes:UP000032875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1500E {ECO:0000313|EMBL:EIK83056.1,
RC ECO:0000313|Proteomes:UP000032875};
RX PubMed=22609915; DOI=10.1128/JB.00056-12;
RA Ahmed A., Earl J., Retchless A., Hillier S., Rabe L., Cherpes T.,
RA Powell E., Janto B., Eutsey R., Hiller N.L., Boissy R., Dahlgreen M.,
RA Hall B., Costerton J., Post J.C., Hu F., Ehrlich G.;
RT "Comparative Genomic Analyses of 17 Clinical Isolates of Gardnerella
RT vaginalis Provide Evidence of Multiple Genetically Isolated Clades
RT Consistent with Subspeciation into Genovars.";
RL J. Bacteriol. 194:3922-3937(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIK83056.1}.
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DR EMBL; ADES01000009; EIK83056.1; -; Genomic_DNA.
DR AlphaFoldDB; I4M1G6; -.
DR PATRIC; fig|698957.3.peg.520; -.
DR Proteomes; UP000032875; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd09755; Cas2_I-E; 1.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR010152; CRISPR-assoc_prot_Cas2_sub.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR01873; cas_CT1978; 1.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF09707; Cas_Cas2CT1978; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|EMBL:EIK83056.1};
KW Hydrolase {ECO:0000313|EMBL:EIK83056.1};
KW Nuclease {ECO:0000313|EMBL:EIK83056.1}.
FT DOMAIN 155..335
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 337 AA; 38146 MW; 5DE3544B08B6C5AC CRC64;
MQEIATGVYV GNFNSRVREE LWKRIKDSVG NGTVTMSFSS RNEIGYDFKT IHSHREVVYS
DGLPLVRIPS NDITEGDIKH GFSNAAHFHN ARKFSNASHK SINTTSNKIK NNLTNENISY
LSYDNVSQTT NFITNNEEIT CTDYWKDCIG KTSKNFVVID CETTGLNSKV DKIIEIGAVK
FIDGKIEEFQ KLININCGSV SNFNKNNFIP NEIIELTGIT DNMLDSYGVG LDSALREFID
FVGKLPVLGY NIQFDMSFLN SALSSLGERF DDSLSINKIF DISRFVKKEK KFLKNYQLKT
VLHEYNISES VPHRALLDAR LTAHLVFNLK GLLKFIS
//
