ID I4Y8A3_WALMC Unreviewed; 636 AA.
AC I4Y8A3;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Dbl-like domain-containing protein {ECO:0000313|EMBL:EIM20195.1};
GN ORFNames=WALSEDRAFT_47842 {ECO:0000313|EMBL:EIM20195.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM20195.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM20195.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH668241; EIM20195.1; -; Genomic_DNA.
DR RefSeq; XP_006959683.1; XM_006959621.1.
DR AlphaFoldDB; I4Y8A3; -.
DR STRING; 671144.I4Y8A3; -.
DR GeneID; 18472430; -.
DR KEGG; wse:WALSEDRAFT_47842; -.
DR eggNOG; KOG3519; Eukaryota.
DR HOGENOM; CLU_016275_0_0_1; -.
DR InParanoid; I4Y8A3; -.
DR OMA; YERGDEM; -.
DR OrthoDB; 1423507at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46006:SF7; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005242}.
FT DOMAIN 16..223
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 266..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 72034 MW; A6E3606888206C58 CRC64;
MVQFDLVENL SQRERTRQEV LWEIVASEAR YVDDLSSLFE GYIKPLLYPY TQNKDSISIP
ENFKLLLETL GNFILPNHVS LSKDLKTRHA AQYPLIRSLA DIFLIHSHNL QYYSLYVLHL
EISLSVIDES INLAKSTGNM NKRSDLYNSW KLGKRLLDLE DAAQRDNEAG LAISLLKPFQ
RLLKYPLLFR NLLFNSDPSM IEYESTLKMV DQVESIVRSI EDRKIQIEER DKTRDVLARI
EGIEKERSLM APKPGRLLMK ETSLQVPNKS KHGSLPPPQK PQVAKKTSVR RLSDLLPSGT
TIHLEDKNNF TKKDLWHVEF NDVTLLCQRT ARTTLPIASN DKSTPSVKRS SLSSNRSDSL
RQNGRNLYRF IKIAKWNITD QSNEGIVSMN AILRSRSNST DVGRQQIPGK PFPTSNPDSR
SPTLNNVDNS TPDDMKSRAS TKMSFSYAKG DEITPRIKLR PRQMPHSQKN SQNEIQNVRM
AAAKFGTRLR PSNASQTSIN VMNDRPSSRA TTTGAPMRQK EVVVARTLTP QPPPTSSKAK
LETMNSSTRK VNHRKAQLYN ERSPSTSPAH KKHTSTGDID ASPTGSISST SSMETQTNVR
QPLQRKSRAP SQDSGMLLVR VAEQYLRESE PEVQQT
//
