ID I4YB52_WALMC Unreviewed; 360 AA.
AC I4YB52;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=GTP-binding protein {ECO:0000256|RuleBase:RU367014};
GN ORFNames=WALSEDRAFT_54758 {ECO:0000313|EMBL:EIM21194.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM21194.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM21194.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- FUNCTION: GTPase involved in activation of the TORC1 signaling pathway,
CC which promotes growth and represses autophagy in nutrient-rich
CC conditions. {ECO:0000256|RuleBase:RU367014}.
CC -!- SUBUNIT: Component of the GSE complex. {ECO:0000256|RuleBase:RU367014}.
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR EMBL; JH668234; EIM21194.1; -; Genomic_DNA.
DR RefSeq; XP_006958866.1; XM_006958804.1.
DR AlphaFoldDB; I4YB52; -.
DR STRING; 671144.I4YB52; -.
DR GeneID; 18472691; -.
DR KEGG; wse:WALSEDRAFT_54758; -.
DR eggNOG; KOG3886; Eukaryota.
DR HOGENOM; CLU_044099_1_0_1; -.
DR InParanoid; I4YB52; -.
DR OMA; QQKDHIF; -.
DR OrthoDB; 33171at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR GO; GO:1990131; C:Gtr1-Gtr2 GTPase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR PANTHER; PTHR11259:SF1; RAS-RELATED GTP-BINDING PROTEIN; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367014};
KW Reference proteome {ECO:0000313|Proteomes:UP000005242}.
FT REGION 341..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 41027 MW; 04C4ED16767EBDE2 CRC64;
MKKKVLLMGK SGSGKTSMRS IIFNSQSSDS TSTVQATLSI EAQSLQLLSS LSLNIWDCGG
QTNFLSSYIS HQRADVFKDV GVLIYVFDVT TPTNQSSDEL SWFSQCLEGL KEYRKDNDSL
KVFILVNKMD LVSKQDIYAV FNRRRNEIFQ SVDQIIKYND NIEVECFMTS IWDQSLYKAW
SKIVTKLLPS SSKMTGALTH FARQAHATEV VLFERTTFLV IGQTTLNKYG EEEIDLEDED
DNDEEYINVT NRNIKLSRHR FEKISQLIKS FKHSCSKLNN QFNSMQISEK YYNAVLEPLT
VNTYILVITD NTNISPSAIQ MNIRLAKPYF EKVEHSFIDT NTASQPTSSS SSIKSEKSIN
//
