ID I4YEM1_WALMC Unreviewed; 552 AA.
AC I4YEM1;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=WALSEDRAFT_28159 {ECO:0000313|EMBL:EIM22413.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM22413.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM22413.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; JH668228; EIM22413.1; -; Genomic_DNA.
DR RefSeq; XP_006957659.1; XM_006957597.1.
DR AlphaFoldDB; I4YEM1; -.
DR STRING; 671144.I4YEM1; -.
DR GeneID; 18471028; -.
DR KEGG; wse:WALSEDRAFT_28159; -.
DR eggNOG; ENOG502SA0Q; Eukaryota.
DR HOGENOM; CLU_493646_0_0_1; -.
DR InParanoid; I4YEM1; -.
DR OMA; LANGNCR; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15710:SF4; E3 UBIQUITIN-PROTEIN LIGASE IRUKA; 1.
DR PANTHER; PTHR15710; E3 UBIQUITIN-PROTEIN LIGASE PRAJA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 250..318
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 61423 MW; 1B4D4EC31EDCD45D CRC64;
MADRERREAN DERAQTPQNE QNEQNEQNEH FAGFNRTFIV QLDDFVDGNQ SANAGTDRDS
GAEQPPEGPG RFHIHFLTLS HSRSLERPAR PVLPFQILLS SFMAALRARN GAGNGDNNTG
DFAGMGGHIQ IERGPLLPEF YPMHQHHHSE GHAHAHPPTP TNNPANGNGE MGERSSLLER
IEELRSRNPY GEQGAFPPPF TITINFPIAG GLHHEKKPDP ARAERILSAL PKLHKGVTRR
MSRVGIETTC GVCLDSLNAR AELQKPETEE GEASTSAVPP EEEARREEEI VALPCSHVFH
SNCLRPWFAL HTLCPMCRFD LDPESMTMST PPPEENRSEG DGNPFVSIIE RLVRGNRERA
GRTQQQEAEQ SNNGGRAESA FSARQNRHHP YARTRSATDP RGERSERALR GVRADENANN
ATANTHPDTR SAEEEMPRPA PPPKKFEIPK ASRSLEDILV KRERESGFRC DMKDCKLGPT
DESDALTTAN MLSIGGSEKP ACAHFLHSHC YHLANSGCRY YNLEHTHDDG RVDSKCPVCK
AAGRVHKHEL AY
//
