ID   I4Z8M4_9BACT            Unreviewed;       717 AA.
AC   I4Z8M4;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:EIM32566.1};
GN   ORFNames=PrebiDRAFT_0828 {ECO:0000313|EMBL:EIM32566.1};
OS   Prevotella bivia DSM 20514.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=868129 {ECO:0000313|EMBL:EIM32566.1, ECO:0000313|Proteomes:UP000002786};
RN   [1] {ECO:0000313|EMBL:EIM32566.1, ECO:0000313|Proteomes:UP000002786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20514 {ECO:0000313|EMBL:EIM32566.1,
RC   ECO:0000313|Proteomes:UP000002786};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Munk A.C.C., Kyrpides N., Mavromatis K.,
RA   Detter J.C., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "Improved High-Quality Draft genome of Prevotella bivia DSM 20514.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH660660; EIM32566.1; -; Genomic_DNA.
DR   RefSeq; WP_004336847.1; NZ_JH660660.1.
DR   AlphaFoldDB; I4Z8M4; -.
DR   GeneID; 78530829; -.
DR   HOGENOM; CLU_009289_6_4_10; -.
DR   Proteomes; UP000002786; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR   Gene3D; 3.30.10.20; -; 1.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03793; PASTA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SMART; SM00740; PASTA; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR   PROSITE; PS51178; PASTA; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000313|EMBL:EIM32566.1};
KW   Cell division {ECO:0000313|EMBL:EIM32566.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002786};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          659..717
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
SQ   SEQUENCE   717 AA;  79286 MW;  DECD5A9047826832 CRC64;
     MNKFNNKESI KWYFLTTVGI VFFAFLIMIK AANTMTVKRD YWMQVAALQK KDSVKIKPIR
     GNILSTDGEL MASSLPEFKI YMDFDALKEA GNDTAFVDSI NFISKGLNEI FPEKSAQAFK
     QHLLEGFHKK SRHWAIWDAR IAYNTFKDVQ NLPIFHLSKF KSGFHWEEFN ARRRPFGSLA
     QRTIGDMFGA KDSARCGLEL SFDSILRGTN GIIHRRKVRN KFLNITDTAP IDGADIVTTI
     DVGMQDLAER ALIDELREIN GNVGVAIVME VATGDVKAIV NMDKCDDGEY REIKNHAVSD
     LLEPGSVFKT ASIMTVLDDG LVDTTYTIAT GAGVWNMYGR DMKDHNWRKG GYGDLMLPWT
     LKYSSNVGVS RIIDLHYHNN PEQFVQGIYD LGLATDLNLP IIGYSPAKIR MPHKNKRGQY
     DNWSATALPW MSIGYETQVP PISTLAFYNA IANNGKMMRP RFVKQIIKNG EVIADYPPEV
     LKKQIAKETT ITQIRRILTE VVSEGLGKKA GSDKFAVAGK TGTAQMSKGA LGYKAGGVNY
     LLSFAGFFPA DKPKYSCIVC IQKTGLPASG GGMSGVVFHH IAEGIMAQDL KLSVTDARNQ
     SSILIPSAKT GNILAADYVL NALGYNAKNG WAGAYPFGNP IWGSVTDTNN SLVIQKRNYS
     NNKIVPDVHG MGARDAVYLL EQRGLKVKII GRGKVIQQSL APGNKIKKGE ACIINLG
//