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Database: UniProt
Entry: I5B2I8_9DELT
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Original site: I5B2I8_9DELT 
ID   I5B2I8_9DELT            Unreviewed;       472 AA.
AC   I5B2I8;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   05-JUL-2017, entry version 34.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=DespoDRAFT_01785 {ECO:0000313|EMBL:EIM63701.1};
OS   Desulfobacter postgatei 2ac9.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulfobacter.
OX   NCBI_TaxID=879212 {ECO:0000313|EMBL:EIM63701.1, ECO:0000313|Proteomes:UP000005778};
RN   [1] {ECO:0000313|EMBL:EIM63701.1, ECO:0000313|Proteomes:UP000005778}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2ac9 {ECO:0000313|EMBL:EIM63701.1,
RC   ECO:0000313|Proteomes:UP000005778};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Land M.L., Hauser L., Orellana R., Lovley D., Woyke T.J.;
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EIM63701.1, ECO:0000313|Proteomes:UP000005778}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2ac9 {ECO:0000313|EMBL:EIM63701.1,
RC   ECO:0000313|Proteomes:UP000005778};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Held B., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Orellana R.,
RA   Lovley D., Woyke T.;
RT   "Improved High-Quality Draft sequence of Desulfobacter postgatei
RT   2ac9.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CM001488; EIM63701.1; -; Genomic_DNA.
DR   RefSeq; WP_004072940.1; NZ_CM001488.1.
DR   EnsemblBacteria; EIM63701; EIM63701; DespoDRAFT_01785.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005778; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005778};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005778}.
FT   DOMAIN      167    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      378    446       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     175    182       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   472 AA;  53656 MW;  530FCA8DC1280EC0 CRC64;
     MDSFLKEVKL HIKELVPDHC YRMWIEPVVL STHDAETIVL SVPNDFYVKR LKENYQGYFE
     EGFLRLGQKG RIEFKVGKKK LRSGQINSNF GQTQKNRAQT TSGVMPGILS PLSFPSDFHP
     QLPGMTPAFH CGRMLKKNFT FDDFVVGDNS SFAYTASLYL AQGKLNGTGV LFLLGKTGLG
     KSHLSQAVGH HMLSQDGGKR VFYVTAEDFT NEMIYSLRNN SIDQFKEKYR LKCDVLILED
     VHFLTGKSAT QKELAMTLDY LIDADKKIIF SGCERPDEIP KLNDNLKSRL NMGVVTEIKA
     PDFGTRVKIL NKKSKAIQCV LPTPVTEYIA QEACNDVRQL ESALLSVVTR GQLMNRKIDI
     ELARNVLEKM TGTRKRITID LIKKMVCEAF EVSEQELVSK SRKQRIVKPR QVAIFLSKKY
     TDQPIKTIGA SFKRYHATAI YSINAVEKEM EQKGQRYEQI RYLADKLESG SF
//
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