ID   I6B166_9BACT            Unreviewed;       957 AA.
AC   I6B166;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Putative Zn-dependent peptidase {ECO:0000313|EMBL:EIQ01008.1};
GN   ORFNames=OpiT1DRAFT_05569 {ECO:0000313|EMBL:EIQ01008.1};
OS   Opitutaceae bacterium TAV1.
OC   Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae.
OX   NCBI_TaxID=278956 {ECO:0000313|EMBL:EIQ01008.1, ECO:0000313|Proteomes:UP000004921};
RN   [1] {ECO:0000313|EMBL:EIQ01008.1, ECO:0000313|Proteomes:UP000004921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAV1 {ECO:0000313|EMBL:EIQ01008.1,
RC   ECO:0000313|Proteomes:UP000004921};
RX   PubMed=22535930; DOI=10.1128/JB.00264-12;
RA   Isanapong J., Goodwin L., Bruce D., Chen A., Detter C., Han J., Han C.S.,
RA   Held B., Huntemann M., Ivanova N., Land M.L., Mavromatis K., Nolan M.,
RA   Pati A., Pennacchio L., Pitluck S., Szeto E., Tapia R., Woyke T.,
RA   Rodrigues J.L.;
RT   "High-Quality Draft Genome Sequence of the Opitutaceae Bacterium Strain
RT   TAV1, a Symbiont of the Wood-Feeding Termite Reticulitermes flavipes.";
RL   J. Bacteriol. 194:2744-2745(2012).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; JH660698; EIQ01008.1; -; Genomic_DNA.
DR   AlphaFoldDB; I6B166; -.
DR   HOGENOM; CLU_008156_0_0_0; -.
DR   Proteomes; UP000004921; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   PANTHER; PTHR43690:SF17; PROTEIN YHJJ; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..957
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003702303"
FT   DOMAIN          48..172
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          208..256
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          703..882
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          253..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  104044 MW;  98A323E5E83D34BD CRC64;
     MRLLTAFLLA GLLVSSAFAA DAAAPAVTAL RPDPELREGT LDNGLRYIVR RNSEPQHRAS
     LRLVVLAGSF HETDAQRGLA HFLEHMAFNG STHYPPRTLI KFFQRMGMGF GGDTNAWTSF
     DHTAYLLELP DTKPETLAEG LRVFGDYAGG LLLDPSEIDR ERGVILSEKR TRDSAEYRAS
     IASYEFLFAG TLLPRRLPIG EESVIKNATR DDFLDLYNTW YRPERMAVIA VGDFDPDAVV
     AEIKNNKNLA SVADRAPARP EPDMGKLAAA DRPGDDAASS AGILASAHYE SDAGATTVSI
     NAIRPWNREP DSVQKRLREL PRDLASAMLN RHLEILAKKE NAPFSQASVS IGEYFRFIHS
     ASLRLTTTPD HWSDALATGE QELRRALQFG FRESELREAR ANYKNALEQA VKTDPTRDSP
     DRASELIDSV VDEIVPTTPA DDLALLGPAL DAITPEDCHE ALRADFSTPA GLQVFVAGNT
     RLAEAADDAS AAIVAAWKKS ADSPVTPSAD TAADAFAYTD FGPAGKITER RHIDDLDVTL
     VTFANGLRLN LKKTDFKTGE IQVRARVGTG RLRLPGNQPG LDFYAGLTFT AGGLGKHSTD
     DLRSLLAGRN VGVGFNVADD AFVFSGVTTP ADLLLELQLL AAHITDPGYR PEAARLAEKN
     LEQFYTRLAH SASGPLQTIV PRLLASGDPR FGLPTRAEAS DRTLGEVKAW LAPHLASGAI
     ELAVVGDIDI DATLQAVAAT LGALPDRAPR PARDALADVL RVDVPAKSVE ETFTVPSTIP
     KGIVALWWPT RDALDATPAR RLNLLADIFT DRLREVVREK IGGAYSPYAA SAPSDVFPGY
     GFILTNITVD PGHAVEIAAA VTRIAQELHD DGVTDDEITR ARLPVLTALR ESARTNEYWL
     GIVLAAAQEQ PQRLDWARTR YSDYESITKA DIDALAKTYL APDRAFRFTV LPVDEKK
//