ID I6MHK4_ANTMR Unreviewed; 248 AA.
AC I6MHK4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Bone morphogenetic protein {ECO:0000313|EMBL:AEK98900.1};
DE Flags: Fragment;
GN Name=BMP4 {ECO:0000313|EMBL:AEK98900.1};
OS Antidorcas marsupialis (Springbok).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Antilopinae; Antidorcas.
OX NCBI_TaxID=59523 {ECO:0000313|EMBL:AEK98900.1};
RN [1] {ECO:0000313|EMBL:AEK98900.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1 {ECO:0000313|EMBL:AEK98899.1}, 2
RC {ECO:0000313|EMBL:AEK98900.1}, 4 {ECO:0000313|EMBL:AEK98902.1}, and 6
RC {ECO:0000313|EMBL:AEK98904.1};
RA Van Aswegen E., Labuschagne C., Grobler J.P.;
RT "Phenotypic differences, spatial distribution and diversity at the Cytb and
RT BMP4 genes in springbok (Antidorcas marsupialis).";
RL Mamm. Biol. 77:391-396(2012).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JN254611; AEK98899.1; -; Genomic_DNA.
DR EMBL; JN254612; AEK98900.1; -; Genomic_DNA.
DR EMBL; JN254614; AEK98902.1; -; Genomic_DNA.
DR EMBL; JN254616; AEK98904.1; -; Genomic_DNA.
DR AlphaFoldDB; I6MHK4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 126..248
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 123..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEK98900.1"
SQ SEQUENCE 248 AA; 28578 MW; 9A05E0B8C2189168 CRC64;
FREQVDQGPD WEQGFHRINI YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA
VLRWTREKQP NYGLAIEVTH LHQTRTHQGQ HVRISRSLPQ GSGDWAQLRP LLVTFGHDGR
GHALTRRRRA KRSPKHHPQR ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD
CPFPLADHLN STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM
VVEGCGCR
//
