ID   I6NDL8_ERECY            Unreviewed;      1017 AA.
AC   I6NDL8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   OrderedLocusNames=Ecym_5405 {ECO:0000313|EMBL:AET40160.1};
OS   Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS   NRRL Y-17582) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=931890 {ECO:0000313|EMBL:AET40160.1, ECO:0000313|Proteomes:UP000006790};
RN   [1] {ECO:0000313|EMBL:AET40160.1, ECO:0000313|Proteomes:UP000006790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC   {ECO:0000313|Proteomes:UP000006790};
RX   PubMed=22384365;
RA   Wendland J., Walther A.;
RT   "Genome evolution in the Eremothecium clade of the Saccharomyces complex
RT   revealed by comparative genomics.";
RL   G3 (Bethesda) 1:539-548(2011).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; CP002501; AET40160.1; -; Genomic_DNA.
DR   RefSeq; XP_003646977.1; XM_003646929.1.
DR   AlphaFoldDB; I6NDL8; -.
DR   STRING; 931890.I6NDL8; -.
DR   GeneID; 11468481; -.
DR   KEGG; erc:Ecym_5405; -.
DR   eggNOG; KOG1967; Eukaryota.
DR   HOGENOM; CLU_005943_1_0_1; -.
DR   InParanoid; I6NDL8; -.
DR   OMA; FSFMPEF; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000006790; Chromosome 5.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006790};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          49..312
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          566..966
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1017 AA;  116065 MW;  39017D69E6CD1625 CRC64;
     MAYTTEQLHG DIVSLLANVD INNEHTNKLA RKIANAIDKQ MVKLLEVVIS LRDYMTSEDD
     GTRLKSMRCL SSILANLGET VLMKNDVLVV FEFYKNRTDD SACLEEIFHG ISSLVKMRYF
     SSGQIMPLLN ILKDQYQPSS HLAATRYLGF KILDNLLQRF HTVISNDKLM NDYFIRTFIL
     LANGEKDPKN LLLSFSLNSD ICKMLQNIDS FKEDLFDILF CYFPITFKPP KNDPYKISTE
     DLKLSLRNAI SSTPTFAEDA FANLVDKMTA SSPSVKNDTI LTLKMCIKSS AAEKCIENWL
     PIWQALKFEI MNNNDTEDPA VTQAEFNNYK ECLSVISVLA EKFLSFGEAV FDKFYSHIFD
     ELKPNFDYEK DLKQSCGILS SIASVNATSF NKVMDNVLPS FFSKNEELDI PKQRLLILNL
     SFFFDAYIKV FGETGKAEHN HEVTNNKLLG HKDEIIMVLG KALTSSKVEV SLRTLSIIEF
     TELVKMNGYL THEEGFMIVQ YLTETILTDD NKNIYIACLE GLKVISEHYE DIIREVLLKQ
     LLELLPNEPA VNQPRLNDEQ INLDTVLKVI VDFTSTTHKL VKESVIGILE KLCTVAKMDN
     SEDYCFMFIS CLHTLLSSNI KLFDIEHCSE LKNIVYEKLL DLVLNCNSIY ENDHNLIISS
     SILWSLNLKS DKITHQEELE KQVKWFVQDK NIINLPSRSA VVFLNILSGL DKKCEFPENV
     DLLKNVVSLL RNPETNITSF EKLAYLQLIS LLINKWCDDE SVDGLIYTTN RSTITLEIMA
     WAAKGLVMKN SPFAVKYLDL FMELLQVAEY SASVTPLFEI LVLDTPIFRT VKGISWNHNV
     RLLYKQKLFS YVAVKLVDGF KATTDMKIKS NYLTALSLIL RNTPADITIT YISELLPLLL
     QALELKNSDV RVSSLQTLMD TIEQNSQLVA QHIHSLVPQL LQLIHQDNYN SVTVRLLSLR
     MLRALTYGIP LNYLLPFKED IVTGLVVALG DKKRVVRKQC IDTRQSYYEL GRVVQDS
//