ID I6NQS9_OVICA Unreviewed; 253 AA.
AC I6NQS9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AEX28228.1};
DE Flags: Fragment;
GN Name=DRA {ECO:0000313|EMBL:AEX28228.1};
OS Ovis canadensis (Bighorn sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=37174 {ECO:0000313|EMBL:AEX28228.1};
RN [1] {ECO:0000313|EMBL:AEX28228.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22750296; DOI=10.1016/j.gene.2012.06.048;
RA Subramaniam R., White S.N., Herrmann-Hoesing L.M., Srikumaran S.;
RT "MHC class II DR allelic diversity in bighorn sheep.";
RL Gene 506:217-222(2012).
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR EMBL; JN166445; AEX28228.1; -; mRNA.
DR AlphaFoldDB; I6NQS9; -.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR CDD; cd05767; IgC1_MHC_II_alpha; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..253
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003705644"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..191
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 253
FT /evidence="ECO:0000313|EMBL:AEX28228.1"
SQ SEQUENCE 253 AA; 28420 MW; 96BFA69AAEF7F7A8 CRC64;
MAITRVPILG LFITVLISLQ ESWAIKEDHV IIQAEFYLNP EESAEFMFDF DGDEIFHVDM
QKKETVWRLP EFGRFASFEA QGALANMAVM KANLDIMIKR SNNTPNTNVP PEVTLLPNKP
VELGEPNTLI CFTDKFSPPV ISVTWLRNGI PVTDGVSQTV FLPRDDHLFR KFHYLPFLPT
TEDVYDCKVE HWGLNEPLLK HWEYEAPAPL PETTENAGCA LGLIVALVGI IAGTIFIIKG
VRKANTVEGR GPL
//
