ID I6SCT6_9TELE Unreviewed; 206 AA.
AC I6SCT6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Homeodomain protein HoxA4ai {ECO:0000313|EMBL:AFM74330.1};
DE Flags: Fragment;
GN Name=HoxA4ai {ECO:0000313|EMBL:AFM74330.1};
OS tetraploid Carassius auratus red var. x Megalobrama amblycephala
OS (tetraploid red crucian carp x blunt snout bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinoidei intergeneric hybrids.
OX NCBI_TaxID=1200843 {ECO:0000313|EMBL:AFM74330.1};
RN [1] {ECO:0000313|EMBL:AFM74330.1}
RP NUCLEOTIDE SEQUENCE.
RA Yang R.;
RT "The evolution of Hox gene clusters in tetraploid hybrids derived from red
RT crucian carp x blunt snout bream.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC {ECO:0000256|RuleBase:RU004442}.
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DR EMBL; JQ901468; AFM74330.1; -; Genomic_DNA.
DR AlphaFoldDB; I6SCT6; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45771:SF2; HOMEOBOX PROTEIN HOX-A4; 1.
DR PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 145..205
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 147..206
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 40..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 206
FT /evidence="ECO:0000313|EMBL:AFM74330.1"
SQ SEQUENCE 206 AA; 23889 MW; 0E8A0F03382E9239 CRC64;
MIMSSYLINS NYIEPSFPPC EEYQQNGYMP VSSDYYERPK DAGFPHHEEA SYPRSNYQEP
SYDYGTVSTN GLNDFTDRHH AQPQSVLQNH GPRLTTESCA GSAANKDCSL VSEALPGAQK
GKEPVVYPWM KKVHVNSVTA SYSGGVPKRS RTAYTRQQAL ELEKEFHFNR YLTRRRRVEI
AHTMCLSERQ VKIWFQNRRM KWKKDH
//
