ID I6UZF5_9EURY Unreviewed; 285 AA.
AC I6UZF5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Probable cobalamin biosynthesis protein CobD {ECO:0000256|ARBA:ARBA00016185, ECO:0000256|HAMAP-Rule:MF_00024};
GN Name=cobD {ECO:0000256|HAMAP-Rule:MF_00024};
GN ORFNames=PFC_00545 {ECO:0000313|EMBL:AFN03083.1};
OS Pyrococcus furiosus COM1.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=1185654 {ECO:0000313|Proteomes:UP000006216};
RN [1] {ECO:0000313|EMBL:AFN03083.1, ECO:0000313|Proteomes:UP000006216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COM1 {ECO:0000313|EMBL:AFN03083.1,
RC ECO:0000313|Proteomes:UP000006216};
RX PubMed=22636780; DOI=10.1128/JB.00439-12;
RA Bridger S.L., Lancaster W.A., Poole F.L.II., Schut G.J., Adams M.W.;
RT "Genome Sequencing of a Genetically-Tractable Pyrococcus furiosus Strain
RT Reveals a Highly Dynamic Genome.";
RL J. Bacteriol. 194:4097-4106(2012).
CC -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC aminopropanol on the F carboxylic group.
CC {ECO:0000256|ARBA:ARBA00003384, ECO:0000256|HAMAP-Rule:MF_00024}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953, ECO:0000256|HAMAP-Rule:MF_00024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|HAMAP-Rule:MF_00024}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_00024}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family.
CC {ECO:0000256|ARBA:ARBA00006263, ECO:0000256|HAMAP-Rule:MF_00024}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00024}.
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DR EMBL; CP003685; AFN03083.1; -; Genomic_DNA.
DR RefSeq; WP_011011410.1; NC_018092.1.
DR AlphaFoldDB; I6UZF5; -.
DR GeneID; 41712086; -.
DR KEGG; pfi:PFC_00545; -.
DR PATRIC; fig|1185654.4.peg.110; -.
DR HOGENOM; CLU_054212_0_2_2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000006216; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00024; CobD_CbiB; 1.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR NCBIfam; TIGR00380; cobal_cbiB; 1.
DR PANTHER; PTHR34308; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR PANTHER; PTHR34308:SF1; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_00024};
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW Rule:MF_00024};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00024};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00024};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00024}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT TRANSMEM 149..166
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
SQ SEQUENCE 285 AA; 32452 MW; CD0DE676909F8640 CRC64;
MDMTLPIALL IDLMFGEPPA IIHPVVGFGK VIEFFDNKYR RRSPYLDFLV GAISSLVVIG
LAFILSHLPN FLPNPFNLIL SIYLLKSSFA IRSLHDHVKR TITPDLEEKR RAVSMIVSRD
TKSLDEPHLN SAAIESLSEN INDSVIAPLF YYLIFGLPGA VVYRAVNTLD AMIGYRNEKY
EYFGKFAARL DDLLNFVPAR ITVLLFLSLG GRKVIRYYRM AKYKINSDKP IAAMSAVLGV
WLEKPNYYKF PGRRPENEDI KRALKVYWII VVEFLLIVAI ILYGG
//
