ID I6V071_9EURY Unreviewed; 139 AA.
AC I6V071;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Hydrogenase maturation factor HypA {ECO:0000256|HAMAP-Rule:MF_00213};
GN Name=hypA {ECO:0000256|HAMAP-Rule:MF_00213,
GN ECO:0000313|EMBL:AFN03408.1};
GN ORFNames=PFC_02215 {ECO:0000313|EMBL:AFN03408.1};
OS Pyrococcus furiosus COM1.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=1185654 {ECO:0000313|Proteomes:UP000006216};
RN [1] {ECO:0000313|EMBL:AFN03408.1, ECO:0000313|Proteomes:UP000006216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COM1 {ECO:0000313|EMBL:AFN03408.1,
RC ECO:0000313|Proteomes:UP000006216};
RX PubMed=22636780; DOI=10.1128/JB.00439-12;
RA Bridger S.L., Lancaster W.A., Poole F.L.II., Schut G.J., Adams M.W.;
RT "Genome Sequencing of a Genetically-Tractable Pyrococcus furiosus Strain
RT Reveals a Highly Dynamic Genome.";
RL J. Bacteriol. 194:4097-4106(2012).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC for nickel insertion into the metal center of the hydrogenase.
CC {ECO:0000256|HAMAP-Rule:MF_00213}.
CC -!- SIMILARITY: Belongs to the HypA/HybF family.
CC {ECO:0000256|ARBA:ARBA00010748, ECO:0000256|HAMAP-Rule:MF_00213}.
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DR EMBL; CP003685; AFN03408.1; -; Genomic_DNA.
DR RefSeq; WP_011011735.1; NC_018092.1.
DR AlphaFoldDB; I6V071; -.
DR SMR; I6V071; -.
DR GeneID; 41712420; -.
DR KEGG; pfi:PFC_02215; -.
DR PATRIC; fig|1185654.4.peg.452; -.
DR HOGENOM; CLU_126929_2_0_2; -.
DR Proteomes; UP000006216; Chromosome.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2320.80; -; 1.
DR HAMAP; MF_00213; HypA_HybF; 1.
DR InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR InterPro; IPR000688; HypA/HybF.
DR PANTHER; PTHR34535; HYDROGENASE MATURATION FACTOR HYPA; 1.
DR PANTHER; PTHR34535:SF3; HYDROGENASE MATURATION FACTOR HYPA; 1.
DR Pfam; PF01155; HypA; 1.
DR PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR PROSITE; PS01249; HYPA; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00213};
KW Nickel {ECO:0000256|ARBA:ARBA00022596, ECO:0000256|HAMAP-Rule:MF_00213};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00213}.
FT BINDING 2
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00213"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00213"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00213"
FT BINDING 110
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00213"
FT BINDING 113
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00213"
SQ SEQUENCE 139 AA; 15763 MW; B154B5D00D5CF4FE CRC64;
MHEWALADAI VRTVLDYAQK EGASRVKAVK VVLGELQDVG EDIVKFAMEE LFRGTIAEGA
EIIFEEEEAV FKCRNCGHVW KLKEVKDKLD ERIREDIHFI PEVVHAFLSC PKCGSHDFEV
VKGRGVYISG IMIEKEGEE
//
