ID I6VQ07_9SAUR Unreviewed; 174 AA.
AC I6VQ07;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE SubName: Full=Melanocortin 1 receptor {ECO:0000313|EMBL:AFN15360.1};
DE Flags: Fragment;
GN Name=MC1R {ECO:0000313|EMBL:AFN15360.1};
OS Phyllopezus pollicaris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Phyllodactylidae; Phyllopezus.
OX NCBI_TaxID=298116 {ECO:0000313|EMBL:AFN15360.1};
RN [1] {ECO:0000313|EMBL:AFN15360.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23025595; DOI=10.1111/j.1558-5646.2012.01682.x;
RA Werneck F.P., Gamble T., Colli G.R., Rodrigues M.T., Sites J.W.Jr.;
RT "DEEP DIVERSIFICATION AND LONG-TERM PERSISTENCE IN THE SOUTH AMERICAN 'DRY
RT DIAGONAL': INTEGRATING CONTINENT-WIDE PHYLOGEOGRAPHY AND DISTRIBUTION
RT MODELING OF GECKOS.";
RL Evolution 66:3014-3034(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JQ827964; AFN15359.1; -; Genomic_DNA.
DR EMBL; JQ827965; AFN15360.1; -; Genomic_DNA.
DR AlphaFoldDB; I6VQ07; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004977; F:melanocortin receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF2; MELANOCYTE-STIMULATING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AFN15360.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..174
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFN15360.1"
FT NON_TER 174
FT /evidence="ECO:0000313|EMBL:AFN15360.1"
SQ SEQUENCE 174 AA; 19865 MW; A3BCF43FFE1A31EB CRC64;
HSPMYYFICC LAVSDMLVSV SNCVETFFII LIDHKVLVLE HETGRYMNDI MDMLICSSFM
ASLSFLGAIA IDRYITIFYA LRYNSIMTIR RAAIVIAAIW VVSVSASTIF IAYDDGKAVV
LCLLTYLLFM LTMIMALYIH MFMLARQHTR RISRMHRKHT GPQVTNLKGA ITLT
//
