ID I6WV37_9POLY Unreviewed; 668 AA.
AC I6WV37;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805};
OS Deltapolyomavirus decihominis.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Deltapolyomavirus.
OX NCBI_TaxID=1208309 {ECO:0000313|EMBL:AFN43007.1, ECO:0000313|Proteomes:UP000125591};
RN [1] {ECO:0000313|EMBL:AFN43007.1, ECO:0000313|Proteomes:UP000125591}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10ww {ECO:0000313|EMBL:AFN43007.1};
RX PubMed=22966183; DOI=10.1128/JVI.01690-12;
RA Buck C.B., Phan G.Q., Raiji M.T., Murphy P.M., McDermott D.H.,
RA McBride A.A.;
RT "Complete genome sequence of a tenth human polyomavirus.";
RL J. Virol. 86:10887-10887(2012).
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JX262162; AFN43007.1; -; Genomic_DNA.
DR Proteomes; UP000125591; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039576; P:disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039645; P:perturbation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1310.20; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR016392; Lg_T_Ag_polyomavir.
DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003133; T_Ag_DNA-bd.
DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR Pfam; PF06431; Polyoma_lg_T_C; 1.
DR Pfam; PF02217; T_Ag_DNA_bind; 1.
DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS51287; T_AG_OBD; 1.
DR PROSITE; PS51341; ZF_LTAG_D1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW G1/S host cell cycle checkpoint dysregulation by virus
KW {ECO:0000256|ARBA:ARBA00023309};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00671}.
FT DOMAIN 12..94
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 163..278
FT /note="T-ag OBD"
FT /evidence="ECO:0000259|PROSITE:PS51287"
FT DOMAIN 287..379
FT /note="T-ag D1-type"
FT /evidence="ECO:0000259|PROSITE:PS51341"
FT DOMAIN 421..580
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
FT DNA_BIND 163..278
FT /note="T-ag OBD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT REGION 108..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 76989 MW; 6555584762E58FFF CRC64;
MDRVLSRDEV KELMALLSLN TAAWGNIPLM QYKYRQTCLK LHPDKGGDGE KMKRLNELFS
KMYTTIEKLR REGEVYFPAK GNPTYGTPEW DQWWEEFNRG WDEDLSCNES FAPSDEEEPG
PSQSASQTAN DTNTPKKRPR ESSSNSTCTP PKRPRNFNPV DFPEVLLEFL SNAIFSNKTL
NSFVLYTTRE KGQFLYEKVP LKFKAMFYSL HEFDGDSLLF LLLSGKHRVS AIKNYCSNLC
TVSFLLVKGC LKAYECYYAL CKTPFKLIKQ SQEHGLSKTD FCEEEKDKVV NWQQICEFAV
EVQCEDPLLL MGMLLDFAKD VEGCSKCEQK KLKHHYKFHE AQNINSKLFK DCKNQKTICQ
QATDWVTAQR RLLILESTRE HLLVLRFKHM FEKMEDICGE VEICQYMAGV AWLSLLMPHF
DEIILFIIKA MTENVPKRRY VLFKGPINSG KTTVAAAILD LLGGKTLNVN CPPDKLAFEI
GCAIDEYMVV FEDVKGQNEG SNSSLTPGMG MSNLDNLRDH LDGCVKVNLE KKHVNKKSQI
FPPGIITMND YFIPPTLQAR MIKTINFRPK LFLRNSLEKN SELLRKRIVQ SGVTLLLLLC
WWQPVIAFHP EIHDNVRYWK ETIEKYVPFG MYHDIRRNIE SGEDPLKDIL ICVDADEDTQ
QDSGINSQ
//
