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Database: UniProt
Entry: I7AIX2_9HIV1
LinkDB: I7AIX2_9HIV1
Original site: I7AIX2_9HIV1 
ID   I7AIX2_9HIV1            Unreviewed;       221 AA.
AC   I7AIX2;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:AFO39094.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AFO39094.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AFO39094.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AFO39094.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Pt2_wk0 {ECO:0000313|EMBL:AFO39094.1};
RX   PubMed=22815755; DOI=10.1371/journal.pone.0040514;
RA   Winters M.A., Lloyd R.M.Jr., Shafer R.W., Kozal M.J., Miller M.D.,
RA   Holodniy M.;
RT   "Development of elvitegravir resistance and linkage of integrase inhibitor
RT   mutations with protease and reverse transcriptase resistance mutations.";
RL   PLoS ONE 7:E40514-E40514(2012).
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DR   EMBL; JX199786; AFO39094.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   4: Predicted;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          3..44
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          54..204
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFO39094.1"
FT   NON_TER         221
FT                   /evidence="ECO:0000313|EMBL:AFO39094.1"
SQ   SEQUENCE   221 AA;  24451 MW;  17B669BAC72421C7 CRC64;
     FLDGIDKAQE EHEKYHNNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM HGQVDCSPGI
     WQLDCTHLEG KIILVAVHVA SGYIEAEVIP AETGQETAYF LLKLAGRWPV KAIHTDNGSN
     FTSNAVKAAC WWAGIKQEFG IPYNPQSQGV VESMNKQLKQ IIGQVRDQAE HLKTAVQMAV
     LIHNFKRKGG IGGYSAGERI VDIIATDIQT KELQKQITKI Q
//
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