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Database: UniProt
Entry: I7CDZ3_PSEPT
LinkDB: I7CDZ3_PSEPT
Original site: I7CDZ3_PSEPT 
ID   I7CDZ3_PSEPT            Unreviewed;       833 AA.
AC   I7CDZ3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE   AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN   OrderedLocusNames=T1E_5615 {ECO:0000313|EMBL:AFO51436.1};
OS   Pseudomonas putida (strain DOT-T1E).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1196325 {ECO:0000313|EMBL:AFO51436.1, ECO:0000313|Proteomes:UP000006503};
RN   [1] {ECO:0000313|Proteomes:UP000006503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DOT-T1E {ECO:0000313|Proteomes:UP000006503};
RX   PubMed=23815283; DOI=10.1111/1751-7915.12061;
RA   Udaondo Z., Molina L., Daniels C., Gomez M.J., Molina-Henares M.A.,
RA   Matilla M.A., Roca A., Fernandez M., Duque E., Segura A., Ramos J.L.;
RT   "Metabolic potential of the organic-solvent tolerant Pseudomonas putida
RT   DOT-T1E deduced from its annotated genome.";
RL   Microb. Biotechnol. 6:598-611(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; CP003734; AFO51436.1; -; Genomic_DNA.
DR   AlphaFoldDB; I7CDZ3; -.
DR   KEGG; ppx:T1E_5615; -.
DR   PATRIC; fig|1196325.3.peg.5577; -.
DR   HOGENOM; CLU_008325_0_1_6; -.
DR   Proteomes; UP000006503; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR   CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR   CDD; cd04862; PaeLigD_Pol_like; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR014146; LigD_ligase_dom.
DR   InterPro; IPR014144; LigD_PE_domain.
DR   InterPro; IPR014145; LigD_pol_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR014143; NHEJ_ligase_prk.
DR   InterPro; IPR033651; PaeLigD_Pol-like.
DR   NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR   NCBIfam; TIGR02778; ligD_pol; 1.
DR   NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR   NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR   PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR   PANTHER; PTHR42705:SF2; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF13298; LigD_N; 1.
DR   Pfam; PF21686; LigD_Prim-Pol; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AFO51436.1};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          307..399
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  93576 MW;  F6BC5ABCBC366EE5 CRC64;
     MAKPLQEYAR KRDFNATPEP SGKRKRGKRA HALQFCIQKH DASHLHYDFR LELDGTLKSW
     AIPKGPSLDP KVRRLAVHVE DHPLDYADFE GHIPEGHYGA GDVIVWDRGI WEPEGDAHEA
     YVKGKLRFRL QGEKLAGVWN LFRTHLAGKK EQWMLVKSHD AQARSETEYS IVEALPDSVL
     SERTLVPRKS AAKKATAPRS SRKRADKVQA APLPAQLQPQ LATLVDSPPS GDWRYEVKFD
     GYRILARIEG QDIRLFTRNG HDWSSKMPRQ VAALRALGID SAWLDGEMVV ADENGMADFQ
     ALQNAFDTEH DERITYYLFD LPFLRGQDLR QLPLQHRRDT LRQLLEHNHS DFIKYSADFD
     EPVESLLDSA CRLKLEGLIG KRADSVYSGR RSPDWIKLKC KQRQEFVIVG YTDPKGSRSG
     FGALLLALHD NERGELRYAG KVGTGFNTTT LASIHTRLKP LEIACPALPS PPAGAEARGV
     HWLRPQLLAE VAFAQMTRDG IVRHSVFHGL RDDKAATAID LERAMPAKTV SNRNKQAKAS
     ENLGELRLTH PDRVIDPTTG VTKREVAEYY AGISQWILPQ LKHRPVALVR APDGLGGELF
     FQKNAGQLHI PNVLSYEKAE AGQAAMVINR PDTLLGAVQM NTLELHTWNA TDKDFDKPDR
     FVLDLDPDPA LPWKAMVEAT QLALTLLDEL GLKVFLKTSG GKGIHVVVPL TRRAGWDEVK
     DFSHAIVNYL AKLFPERLSA VSGPKNRVGR IFIDYLRNGK GATTACAYSL RARDGLPVSV
     PIWREELAQI KAANQWNITN LHERLAEVDD PWADMGKVRQ SITARMRKQL GLE
//
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