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Database: UniProt
Entry: I7EVE6_PHAIB
LinkDB: I7EVE6_PHAIB
Original site: I7EVE6_PHAIB 
ID   I7EVE6_PHAIB            Unreviewed;       475 AA.
AC   I7EVE6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AFO89755.1};
GN   OrderedLocusNames=PGA1_c00010 {ECO:0000313|EMBL:AFO89755.1};
OS   Phaeobacter inhibens (strain ATCC 700781 / DSM 17395 / CIP 105210 /
OS   JCM 21319 / NBRC 16654 / NCIMB 13546 / BS107).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Phaeobacter.
OX   NCBI_TaxID=391619 {ECO:0000313|EMBL:AFO89755.1, ECO:0000313|Proteomes:UP000002914};
RN   [1] {ECO:0000313|EMBL:AFO89755.1, ECO:0000313|Proteomes:UP000002914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17395 {ECO:0000313|EMBL:AFO89755.1,
RC   ECO:0000313|Proteomes:UP000002914};
RX   PubMed=22717884; DOI=10.1038/ismej.2012.62;
RA   Thole S., Kalhoefer D., Voget S., Berger M., Engelhardt T.,
RA   Liesegang H., Wollherr A., Kjelleberg S., Daniel R., Simon M.,
RA   Thomas T., Brinkhoff T.;
RT   "Phaeobacter gallaeciensis genomes from globally opposite locations
RT   reveal high similarity of adaptation to surface life.";
RL   ISME J. 6:2229-2244(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002976; AFO89755.1; -; Genomic_DNA.
DR   RefSeq; WP_014878809.1; NC_018290.1.
DR   ProteinModelPortal; I7EVE6; -.
DR   STRING; 391619.RGBS107_06969; -.
DR   EnsemblBacteria; AFO89755; AFO89755; PGA1_c00010.
DR   KEGG; pga:PGA1_c00010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002914; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002914};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002914}.
FT   DOMAIN      167    297       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      383    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     175    182       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  53542 MW;  57B6EC549879AED5 CRC64;
     MTEDNWGRLR QRLLKTVGQN NFTTWIEPLE FTCVENGVAI FNVPTNFMGN YVSQNFADLI
     LHELNMSGEP VQRLAFRVAA NTAARPTAVD AAGAADDLPL DLDDEALTDL PRARTATGHG
     AAPKDQGETL QAAPLDPRFT FDSFVVGKPN ELAHAAARRV AEGGPVTFNP LVLYGGVGLG
     KTHLMHAIAW ELTARNPELN VLYLSAEQFM YRFVQALRER KMMDFKHLFR SVDVLMVDDV
     QFIAGKDSTQ EEFFHTFNAL VDQNKQIIIS ADRAPGEIKD LEDRVRSRLQ CGLVVDLHPT
     DYELRLGILQ SKVAQQMQTY PDLRIADGVL EFLAHRISTN VRVLEGALTR LFAFASLVGR
     EIDMELTQDC LADVLRASER KITVEEIQRK VSEYYNIRMS DIIGPKRLRS YARPRQVAMY
     LCKQLTSRSL PEIGRRFGGR DHTTVMHGVR RIEELKTIDG QIAEDVEMLR RSLEA
//
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