ID I7FXH1_LOCMI Unreviewed; 904 AA.
AC I7FXH1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Ionotropic receptor {ECO:0000313|EMBL:AFP33229.1};
OS Locusta migratoria (Migratory locust).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Oedipodinae; Locusta.
OX NCBI_TaxID=7004 {ECO:0000313|EMBL:AFP33229.1};
RN [1] {ECO:0000313|EMBL:AFP33229.1}
RP NUCLEOTIDE SEQUENCE.
RA Yang Y., Zhang L., Breer H.;
RT "Identification and characterization of ionotropic receptor in locust,
RT Locusta migratoria.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; JX154136; AFP33229.1; -; mRNA.
DR AlphaFoldDB; I7FXH1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd13717; PBP2_iGluR_putative; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF411; IONOTROPIC RECEPTOR 25A; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AFP33229.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003709753"
FT TRANSMEM 532..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 405..805
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 415..476
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 904 AA; 102883 MW; 19BB29A56BFEEDFA CRC64;
MTPLLLTVTL LSNLLSALGQ TRINYLHVND DKNSIPNKAL KQVVADLSKQ GMIFDGVFKA
TANGSDVEAL IDSMCLEYNT SIDENKKIHV VLDTTLQDVS SEAVKYFTRA LELPTVSASC
GQEGDLRYWR NIDKKQDKYM IQVMPPIDTI PEFIRSFCSA QNLTNAGILF DDTFIMDHKY
KSLLQNVPTR HIINEIKFQN IANQLSTFKQ REVFNYFILG RMDTVNKVLE AAADMEFYGR
QFGWYAITQD EGNPSCQKCG KGASVLHVKP NDAEGTVVGA ENPKLAYQFY YELFRNTFLA
IGQMIKEESW PDMRYIPCEE YEENKNVPPT RKLNLLEALQ QISMLNPGAY GQLMLSSNGH
SHMQFNMTAF NVSLSDNSAT EVGTWAADLD SPFITKVKPS VPVTQYTVVV ALQQPFVIKY
QDENGNTKFK GYCIDLINAI RNITNFEIEI YEVADGKFGN MDEEGRWNGM IKDLIDKKAH
IALGALSVMA ERENVVDFTV PYYDLVGITI LMKKPKTPTS LFKFLTVLEN DVWLCILAAY
FFTSFLMWVF DRWSPYSYQN NREKYKDDEE KREFDLKECL WFCMTSLTPQ GGGEAPKNLS
GRLVAATWWL FGFIIIASYT ANLAAFLTVS RLDTSVESLD DLSKQYKIQY APIANSSAHV
YFQRMAAIEN RFYEIWKDMS LNDSLSEVER AKLAVWDYPV SDKYTKILQA MTEAGFPANI
EEALERVRAS KSSSEGFAFI GDATDIRYQV LTNCDLQMVG EEFSRKPYAI AVQQGSPLKD
QFNNAILQLL NKRKLEKLKE QWWNQNPEKR NDCEKQDDQS DGISIQNIGG VFIVIFVGIG
LACITLAFEY WWYKLRPQHN AVVEAAPPRT KSDSLQALNM MRSSFDKRYG RRQGVALAGV
TNPW
//
