ID I7G1A6_MYCS2 Unreviewed; 354 AA.
AC I7G1A6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:AFP36631.1};
DE EC=1.1.1.169 {ECO:0000313|EMBL:AFP36631.1};
GN OrderedLocusNames=MSMEI_0150 {ECO:0000313|EMBL:AFP36631.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:AFP36631.1, ECO:0000313|Proteomes:UP000006158};
RN [1] {ECO:0000313|EMBL:AFP36631.1, ECO:0000313|Proteomes:UP000006158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000006158};
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [2] {ECO:0000313|EMBL:AFP36631.1, ECO:0000313|Proteomes:UP000006158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000006158};
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001663; AFP36631.1; -; Genomic_DNA.
DR AlphaFoldDB; I7G1A6; -.
DR KEGG; msg:MSMEI_0150; -.
DR PATRIC; fig|246196.56.peg.153; -.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR21708:SF42; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AFP36631.1}.
FT DOMAIN 20..186
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 213..331
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 354 AA; 38020 MW; 98CA33EF27CF2B4F CRC64;
MESRGLSWHT EYKQGGRVRI AVVGAGAIGA YWGAAMHRGG AEVHLIARNA HLHAMREHGV
RVLSDRGDFV AHPNATDDPH EIGPVDYVFL GLKAHSYPSC GPLIEPLLGE HTAVLAAQNG
VPWWYFHELQ GPYRGRRIEA VDPGGATSAV LAPERAIGCV VYPATTIEAP GVIRHLEGTR
FSIGEPSGEI SQRCIALSEA MIAGGLKAPV EADLRSDIWI KLMGNVAFNP LSALTRATMV
EICQNPYTRQ VVVQLMEETL DIASRLGAKP DISIEKRLRG AENVGHHKTS MLQDLEAGKQ
LELDAIVTAV VEMADLTGAP APTLRTVHAA TDLLARTAVP AAVPQEQALK PALR
//
