ID   I7G987_MACFA            Unreviewed;       528 AA.
AC   I7G987;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE   AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE   AltName: Full=Neurofilament 3 {ECO:0000256|ARBA:ARBA00033124};
DE   AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|EMBL:BAE87971.1};
RN   [1] {ECO:0000313|EMBL:BAE87971.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17194215; DOI=10.1371/journal.pbio.0050013;
RA   Wang H.-Y., Chien H.-C., Osada N., Hashimoto K., Sugano S., Gojobori T.,
RA   Chou C.-K., Tsai S.-F., Wu C.-I., Shen C.-K.J.;
RT   "Rate of evolution in brain-expressed genes in humans and other primates.";
RL   PLoS Biol. 5:e13-e13(2007).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AB170908; BAE87971.1; -; mRNA.
DR   AlphaFoldDB; I7G987; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}.
FT   DOMAIN          101..412
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          119..244
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          296..383
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   528 AA;  60265 MW;  99C3F9B7B8824EFC CRC64;
     MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSMLAPR
     LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH
     YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE
     DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE
     EVADLLAQIQ ASHITVERKD YLKTDISTAL KEIRSQLECH SDQNMHQAEE WFKCRYAKLT
     EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ
     DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT
     GPLYTHRQPS VTISSKIQKT KVEAPKLKVQ HKFVEEIIEE TKVEDEKSEM EEALTAITEE
     LAVSMKEEKE EAAEEKGEEP EAEEEEVAAK KSPVKPTAPV VLFIGQWK
//