ID I7GHG5_MACFA Unreviewed; 196 AA.
AC I7GHG5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Macaca fascicularis brain cDNA clone: QorA-11493, similar to human gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1),transcript variant 4, mRNA, RefSeq: NM_021905.1 {ECO:0000313|EMBL:BAE88026.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:BAE88026.1};
RN [1] {ECO:0000313|EMBL:BAE88026.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17194215; DOI=10.1371/journal.pbio.0050013;
RA Wang H.-Y., Chien H.-C., Osada N., Hashimoto K., Sugano S., Gojobori T.,
RA Chou C.-K., Tsai S.-F., Wu C.-I., Shen C.-K.J.;
RT "Rate of evolution in brain-expressed genes in humans and other primates.";
RL PLoS Biol. 5:e13-e13(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR EMBL; AB170963; BAE88026.1; -; mRNA.
DR AlphaFoldDB; I7GHG5; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:BAE88026.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..111
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 102..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22158 MW; 15078A98BC1C3913 CRC64;
MNTWLGIFYG YKGLLLLLGI FLAYETKSVS TEKINDHRAV GMAIYNVAVL CLITAPVTMI
LSSQQDAAFA FASLAIVFSS YITLVVLFVP KMRRLITRGE WQSEAQDTMK TGSSTNNNEE
EKSRLLEKEN RELEKIIAEK EERVSELRHQ LQSRQQLRSR RHPPTPPDPS GGLPRGPPEP
PDRLSCDGSR VHLLYK
//
