ID I7HHA5_9CICH Unreviewed; 374 AA.
AC I7HHA5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vomeronasal type 1 receptor 5 {ECO:0000313|EMBL:BAM35872.1};
GN Name=V1R5 {ECO:0000313|EMBL:BAM35872.1};
OS Trematocara marginatum.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Bathybatini; Trematocara.
OX NCBI_TaxID=1084758 {ECO:0000313|EMBL:BAM35872.1};
RN [1] {ECO:0000313|EMBL:BAM35872.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Piece of fin {ECO:0000313|EMBL:BAM35872.1};
RA Nikaido M., Ota T., Hirata T., Suzuki H., Satta Y., Aibara M.,
RA Mzighani S.I., Sturmbauer C., Hagino-Yamagishi K., Okada N.;
RT "Multiple Episodic Evolution Events in V1R Receptor Genes of East-African
RT Cichlids.";
RL Genome Biol. Evol. 6:1135-1144(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AB704657; BAM35872.1; -; Genomic_DNA.
DR AlphaFoldDB; I7HHA5; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24241:SF186; NEUROPEPTIDE Y RECEPTOR TYPE 6-LIKE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:BAM35872.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..361
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 208..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 41168 MW; 74E59D8B9679AC69 CRC64;
MEELIESIIR ALMFIAGILG NNWLAICSLP RHKSSIRTNE VLFINLAISN LITNYLVDLP
DTMADFAGRW FLGKTYCGVF CFCASLSETS SIFTTLFISI FWHQKLVGSL KRGGAPVQMD
SLCLVGCLLA GSWTVAVVFS VPHFFFFTLE GANDSHEDCI EIFPDPNARQ IYDAIYLTLA
NALPMAGIVF ASAQIVITLL QNHQRIRSHN SDQTKEMVKE ERKRFESKRN KASVSIISGP
TTSKDLRDST STNHIYAVVP APSSPNRQPS GHSLRNAPQN CSVGAQPNLS RPSEIPSKPH
PNSSTQVRAA KSVVAVASVV LVCWLTHLLL HITNNIHTSS IVVEVASYIA ASYTCIIPYI
FLHGVKKLTC SSKR
//
