ID I7HXE8_9CAUD Unreviewed; 577 AA.
AC I7HXE8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
GN Name=PHI92_gene_108 {ECO:0000313|EMBL:CBY99537.1};
GN ORFNames=PHI92_108 {ECO:0000313|EMBL:CBY99537.1};
OS Escherichia phage phi92.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Stephanstirmvirinae; Justusliebigvirus; Justusliebigvirus phi92.
OX NCBI_TaxID=948870 {ECO:0000313|EMBL:CBY99537.1, ECO:0000313|Proteomes:UP000009013};
RN [1] {ECO:0000313|EMBL:CBY99537.1, ECO:0000313|Proteomes:UP000009013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35860-B1 {ECO:0000313|EMBL:CBY99537.1};
RX PubMed=6401818;
RA Kwiatkowski B., Boschek B., Thiele H., Stirm S.;
RT "Substrate specificity of two bacteriophage-associated endo-N-
RT acetylneuraminidases.";
RL J. Virol. 45:367-374(1983).
RN [2] {ECO:0000313|EMBL:CBY99537.1, ECO:0000313|Proteomes:UP000009013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35860-B1 {ECO:0000313|EMBL:CBY99537.1};
RX PubMed=3298958; DOI=10.1016/0076-6879(87)38067-X;
RA Kwiatkowski B., Stirm S.;
RT "Polysialic acid depolymerase.";
RL Methods Enzymol. 138:786-792(1987).
RN [3] {ECO:0000313|EMBL:CBY99537.1, ECO:0000313|Proteomes:UP000009013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35860-B1 {ECO:0000313|EMBL:CBY99537.1};
RX PubMed=22787233; DOI=10.1128/JVI.00801-12;
RA Schwarzer D., Buettner F.F., Browning C., Nazarov S., Rabsch W., Bethe A.,
RA Oberbeck A., Bowman V.D., Stummeyer K., Leiman P.G., Muhlenhoff M.,
RA Gerardy-Schahn R.;
RT "A Multivalent Adsorption Apparatus Explains the Broad Host Range of Phage
RT phi92: a Comprehensive Genomic and Structural Analysis.";
RL J. Virol. 86:10384-10398(2012).
RN [4] {ECO:0000313|Proteomes:UP000009013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22325780; DOI=10.1016/j.str.2011.12.009;
RA Browning C., Shneider M.M., Bowman V.D., Schwarzer D., Leiman P.G.;
RT "Phage pierces the host cell membrane with the iron-loaded spike.";
RL Structure 20:326-339(2012).
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
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DR EMBL; FR775895; CBY99537.1; -; Genomic_DNA.
DR RefSeq; YP_009012440.1; NC_023693.1.
DR GeneID; 22278127; -.
DR KEGG; vg:22278127; -.
DR OrthoDB; 5829at10239; -.
DR Proteomes; UP000009013; Genome.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000009013}.
FT DOMAIN 186..510
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
SQ SEQUENCE 577 AA; 65119 MW; 37825F49259BB238 CRC64;
MNIFAPFATD WYKPGHKQMY NQNTKLIFSN LTPRNDKNFA HYADREARGV IVLGIRRAVT
DALVTMWDSF FKMSRSAAVN KFYRMSKNAL GASAPSAECW EELHDLGYLP LEVRSLPEGV
LCPIGVPVFT VHNTLEKFFW LTNYVETLLS DETWKTMTNA TAAFQYKRIA MAYAMATCDN
IDHVNFQCHD FSLRGLSNIE DGYKSGIAHL ASFTGTDNIL AIETVHDYYG IDYDQFVAGS
IPATEHSVAT TNIGAIVEDL KKHFPHLKDD VDGLRYVAEK EFLRRYIEEI VPEGFCSYVA
DSYDYWAVLT RILVELKESI MSRNGRLVIR PDSGDPVKVV AGYNVESFAN YEDLLNNGIA
TATEVVHLAD VNKYYNVLQD CSVADCIDET YEIPYCEAVG SIQILWEVFG GTINRKGYKV
LDQHIGMIYG DSITVEREYE ILRRLKKKGF AASNIVFGVG SYTYQFNTRD TFGFAVKATG
SIIGEHEILV SKEPKTDPGK RSAKGFIKVV KDTNGKLSLV DNLSFKDIQD EDNELKVIFR
DGTVITPQVE GRDETFTDIR NRVDVEVLRT MGTIQVD
//
