ID I7JAC6_9RICK Unreviewed; 444 AA.
AC I7JAC6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Zn-dependent protease {ECO:0008006|Google:ProtNLM};
GN ORFNames=wOo_01710 {ECO:0000313|EMBL:CCF77993.1};
OS Wolbachia endosymbiont of Onchocerca ochengi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=100901 {ECO:0000313|EMBL:CCF77993.1, ECO:0000313|Proteomes:UP000007516};
RN [1] {ECO:0000313|EMBL:CCF77993.1, ECO:0000313|Proteomes:UP000007516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Adamawa_Cameroon {ECO:0000313|Proteomes:UP000007516};
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE660029; CCF77993.1; -; Genomic_DNA.
DR RefSeq; WP_014868778.1; NC_018267.1.
DR AlphaFoldDB; I7JAC6; -.
DR STRING; 100901.wOo_01710; -.
DR KEGG; woo:wOo_01710; -.
DR PATRIC; fig|100901.6.peg.138; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_0_0_5; -.
DR Proteomes; UP000007516; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR047657; PmbA.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR43421; METALLOPROTEASE PMBA; 1.
DR PANTHER; PTHR43421:SF1; METALLOPROTEASE PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007516}.
FT DOMAIN 21..84
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 117..217
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 224..440
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 444 AA; 48163 MW; 1244B4BD82BE3C1C CRC64;
MDILNIAADI IKLVKKQNQS AEVSIYEINK ISVSQRLSKV EQISQSKNCT VGIRAIVDKT
KAAYISTNDL NNLSNTVSQV VEMAKNVPKD PYINFAVDGG NYTSSTDLGI LDNSVVTIDN
LKKIAEAAEN SAFLCKEVVN SEGASASYSL VNTVLFTVSG FIGSFSKSIF ANQVSVIAGG
KGKMKVGYSY DVACNFYDLK SPRLIGKEAA KRAIDQLNSR SIKTGKLPVI FEKRAAKELV
KSFASAINGS SIVSSSSFLR NSLNTQIFNN RINIIDNPLL PKGIESRPFD GEGIISKKNI
LVKNGVLQNW ILDLYSAKKL NLETTGNAIR ANNAAIVPAA SNFYIENGNI SFEELIEEVK
EGVYITDLFG FGVNLINGDY SQGASGFFIE NGKITYPIHE ITVASNLENM FNNLVVANDL
TFCGQFNSPT IKINEMMIAG SLGN
//
