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Database: UniProt
Entry: I7LTX0_TETTS
LinkDB: I7LTX0_TETTS
Original site: I7LTX0_TETTS 
ID   I7LTX0_TETTS            Unreviewed;       660 AA.
AC   I7LTX0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Eukaryotic aspartyl protease {ECO:0000313|EMBL:EAR87445.3};
GN   ORFNames=TTHERM_00061560 {ECO:0000313|EMBL:EAR87445.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR87445.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
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DR   EMBL; GG662853; EAR87445.3; -; Genomic_DNA.
DR   RefSeq; XP_001007690.3; XM_001007690.3.
DR   AlphaFoldDB; I7LTX0; -.
DR   STRING; 312017.I7LTX0; -.
DR   GeneID; 7841869; -.
DR   KEGG; tet:TTHERM_00061560; -.
DR   eggNOG; KOG2265; Eukaryota.
DR   InParanoid; I7LTX0; -.
DR   OrthoDB; 615305at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EAR87445.3};
KW   Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EAR87445.3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        515..534
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          92..495
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          630..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  76038 MW;  59E09A5B38C2099F CRC64;
     MKKKLNKMNI NKAIIFFFLT FILVNSAKKK NIVYKSNSKD IYELRMQRIN QNNTINVGQI
     VTSIASCDSY HRNVFHNSTW STLMCFERDL SYQISASTAK PKQKNQEFLN LEININSPWS
     WIAGFDCMEC SQELDSYTYQ SLSQVQCEEK CEISKVNKLS KFNPFKINQN QELSKNGGKK
     AAITTQDSGI YGIFLNYMIS FIAYNPNRNI TIKDTVKEKL SFGSYNALED LTTVKKLKVL
     HAQKLSNIQQ IAGQGSIGLG RLDIEFDSKN IEPETHFLKQ LIESVDVEEQ GDMVFGIYIN
     RQNKEIQDFA LTLGGYNAEY SSEVDIEKYF VDLRINKKKS NYQYILPLNS INVLGESFQF
     TEAYITLSSS FLIIPFEILT KIVSYMNSNY SMGCSIVDKK YLMVFCTDIV PRVFNDKEVN
     FQFDNLAISI PFKDFLHVCK HDKIALFNQD ISQSVSNQCI LNIASSPDNK VILGEVFLNK
     RYTIFDIQNN RIGFLPPQTV NFFSDENEKR AFVDLLMKIV TFIFIAGIVA LYFMNTIWKI
     LKSFLNYLGK LIDIQKLPAT NKYSSTQNQQ FQQISQTEGI EIQNNSLNYS FDNKFNVSDK
     NHPVVVPANV IPSFKLHPQK RKIFETKIQK PQNNPNNQQQ KEQNNLIDDN SPKLENIDLL
//
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