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Database: UniProt
Entry: I7LUP6_TETTS
LinkDB: I7LUP6_TETTS
Original site: I7LUP6_TETTS 
ID   I7LUP6_TETTS            Unreviewed;       877 AA.
AC   I7LUP6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TTHERM_00266570 {ECO:0000313|EMBL:EAR95647.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR95647.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG662703; EAR95647.2; -; Genomic_DNA.
DR   RefSeq; XP_001015892.2; XM_001015892.3.
DR   STRING; 5911.EAR95647; -.
DR   EnsemblProtists; EAR95647; EAR95647; TTHERM_00266570.
DR   GeneID; 7846372; -.
DR   KEGG; tet:TTHERM_00266570; -.
DR   InParanoid; I7LUP6; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    424    448       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    469    486       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    555    573       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    658    680       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    798    820       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      111    151       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   877 AA;  100372 MW;  30AF9A9FCEF582C9 CRC64;
     MSLFRSEDME YCRIVLPRES AWETLNELGK NDCIHQVDTD SLLPNIARPF HNQIKRCDEV
     EFMLNDIKGY INKYEGLIIK CKNIKELVEV VFPKVLDTRQ RAGKTYFEEI ENDVIQRYNN
     LKDQIQNLDN ISEKQKQLEE YKQVLNNAQA IMGDAFFMDQ KQSQSDEKID IHGKGLEELK
     SDFNLNKISG IIDTSDVNRF QKFIFRITKG NCFIAFKEAQ ELSTLHSQSR SVFVLMFPGN
     RNGLVYQKAS RICESFNANR FQCPSNQTEF NQKLAEIDRQ IIEGKQIINL TKKNLISYLE
     EFTVVKHNAG CSYVEYLNCY VAKERRIYQA MNCLRISGSV LVGFCWVPTE KVPDAQYALG
     QLANKYSNLP SSTLKVISAG DQKPPTYFKL NDFKAVFQTI VDTYGVPRYK EVNPGLFTIV
     TFPFLFGVMF GDIGHGGLLF IFGLYLLFFK DSILNDKFSS IKALIPARYI IVLMGFFALF
     CGFIYNDFLS LRLDLFGSCF QVNTKTVTDP KTQQQMQEEY VIPKSRDCTY PFGIDPMWGK
     TSNELTFVNS FKMKLAVIFA ITQMCLGISM KAFNSVYFKK WVDFFFEFVP QILFMGLMFG
     YMDYLIFAKW TIDYTDGEYN IPKDAKVPSI ITTMIDMALT LGNVKSENGS IISNQRTIQT
     IILVVSLLCV PMMLFPKPII LHLQNKRKQR LSHIADDHSQ QHLLHGQDED DLARDLEKAQ
     LKLLNSGIDS QKQGGGHGEH EAFGEIFVHQ IIETIEFILG SISNTASYLR LWALSLAHSQ
     LAAVFFDKAL KSGLENANIP MLVIGYLVFA KVTLGVLMAM DVMECFLHAL RLHWVEFQSK
     FYKADGYAFS PFSFVNAIKE AVPSEDDEAE AAKKQKQ
//
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