ID I7M1W3_TETTS Unreviewed; 956 AA.
AC I7M1W3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR97901.3};
GN ORFNames=TTHERM_00279900 {ECO:0000313|EMBL:EAR97901.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR97901.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662656; EAR97901.3; -; Genomic_DNA.
DR RefSeq; XP_001018146.3; XM_001018146.3.
DR AlphaFoldDB; I7M1W3; -.
DR STRING; 312017.I7M1W3; -.
DR GeneID; 7843264; -.
DR KEGG; tet:TTHERM_00279900; -.
DR eggNOG; ENOG502QQYF; Eukaryota.
DR InParanoid; I7M1W3; -.
DR OrthoDB; 180014at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR43336:SF3; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43336; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 124..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 733..890
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 56..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 107963 MW; 6AA2F47983016F28 CRC64;
MNSFNNFTSH LKPNNKIKKE REQSLSLMIP QVQSIPLEGD DNLNTVQQMA SNHIALSQSA
ADQQSSKGGK TPRSKKSSRS KDFKRKLQEL KLHQESQEIH EQVQKLTTVQ KIKYYINKLL
DNNYYTAFMT LVTLYALFAD DIRVITTEKD EDPYFWGASC FALAAFTIEI ILSSIAKDGY
FLGFFFWLDL LSTVSLILDI GWIANEIFDV NSGGKGKASS AASLAKASRA SRVGTRAGRI
VRIVRLVRLV RLYKHAQHAL KKQAKEFEKE QLRLRAQQQD EMRDRGDSKV SSSFNQYQTP
HGFIGNSNHL NIPEIQQNKA LTPSNIIHLR PPTLPPINMD MRGNSHTNRN KEKKQTVMTE
LVRQQSQKKS TFLNQLQREK SIRENQVLPF SQAQDIIQQG VLNDNHIPVL NAERRNIESE
PDNREREKSM SSLPANRSRN ISSLSGKSSG SNTSKGSSFN LSKLQKAETK VGKTLSDKTT
QKVIIIVLAI LISVPLFTLS TYQDPIDSFG PSLSLIYNSQ FMSPGIFDLT VQNYIDFHTA
YRNPLILLMI GNVEYFPKDP NAVDYNNMRE DDYTYYTYSD DSGNVLITSI SSQRQSNIIN
SILSIVRTVT IAIILTVAAV QFNNDVELYL LEPIEAMLKK VTRIAENPLE AAQMEEKEEF
AIEQLKLEGK TKELEEIEQK SKYETVVLEK LIIRIGALLA VGFGEAGSEI IAQNMKLTGQ
VDPMIPGKKI MAVFGFCDIR NFTDVTEVLQ TGVMIFVNEI AQITHGVVDQ YCGQANKNIG
DAFLLVWKFR DKDYLKHIDG TVEFLPNDIT SNFADLSVIS FLKIMAGITL SNNLKKYQYN
QGIKQRLKGY RVRMGFGLHF GWAIEGAIGS SFKIDASYLS PNVNMASRLE AATKQFGTQL
LISGPLRNVL SEKCQKELRH IDCVTVKGSV VPLGINQYLQ TTFYFDTLYQ LRSLYM
//