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Database: UniProt
Entry: I7M742_TETTS
LinkDB: I7M742_TETTS
Original site: I7M742_TETTS 
ID   I7M742_TETTS            Unreviewed;       924 AA.
AC   I7M742;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   20-DEC-2017, entry version 28.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TTHERM_00372530 {ECO:0000313|EMBL:EAR89336.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89336.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG662821; EAR89336.2; -; Genomic_DNA.
DR   RefSeq; XP_001009581.2; XM_001009581.3.
DR   STRING; 5911.EAR89336; -.
DR   GeneID; 7845131; -.
DR   KEGG; tet:TTHERM_00372530; -.
DR   KO; K02154; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    460    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    505    532       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    580    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    614    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    683    705       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    856    875       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      310    330       {ECO:0000256|SAM:Coils}.
FT   COILED      758    778       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   924 AA;  107026 MW;  9026CDE0908EBC99 CRC64;
     MNIFRSENMG YYHLILPRES SWEVMNELGG LSLLHFIDQN PDLPNVNKAF TNYIKRCDEV
     LFKLNLIKKQ MQNFDKEINK PDNFKDLQGY FNKILQEREK AGQTYFEEIE DSVYQKATQL
     EEQINNYTNL QDKQDHLVEY KDVLIKAKTI LGPSFFKNQQ EIDEEASIQS VQESVSGLQQ
     IDINQSQLSL AMRDMNIPLQ KHHGINIESN LKLNYVVGTV SDSDAAKFQK TIFRITKGNS
     WVIMQNLEQK QQNEVSANVM PQKVGRSVFL MLIPGQQAGF INQKIQRICD SFGVNKYQFP
     ETPDKYEKRL QDLDNQIRDS RHLLKLTQRE INDFLETFSQ NRNDCKCSYI EELIYYIEKE
     KLLYTNLNYL KAQSTHYHGN CWLPKDEEES ILKALQNIRL RYPHLPNGQL QEVIPAAGVP
     PTYFKLNDFT RVFQVIVNTY GVPRYKEVNP GLFTIVTFPF LFGVMFGDIG HGFLLFVIGC
     YLCLWKEKIE NDPSSTFKLM LPARYIIIMM GFFATFCGLI YNEFFSIVFN IFGSCYNLEE
     INGTQTITKI PDCVYDFGFD PIWMLTSNNL TFQNSFKMKF AVIIAIIHMS LGICMKAFNA
     IFFKSKADFY FEFLPQLLFL LLTFGYMDFL IIIKWVQNWT QHILEANPPP SIITLMINIP
     LKGADPAGAA LFGPSDAGIQ KSIGIIFLLI AIVCVPIMLL PKPFIQNYIN KKKHQALNGD
     LDDHNQDKKY LIREEHKSEI SPRHDSQQGH NNLQEIPLDD LQKDLEQYQK NIEIHHNVNN
     EQISDDHHIE VGEHEGFADL FVHQVIETIE FVLGSISNTA SYLRLWALSL AHGQLSRVFF
     QKALQPFIEM DGGVQIIALI IGYYVFALVT FGVLMCMDVM ECFLHALRLH WVEFQSKFYK
     ADGYAFVPYS IEKHFIELSQ SKDA
//
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