ID I7M7U7_TETTS Unreviewed; 756 AA.
AC I7M7U7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=DNA mismatch repair protein, putative {ECO:0000313|EMBL:EAR96035.2};
GN ORFNames=TTHERM_00127000 {ECO:0000313|EMBL:EAR96035.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96035.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GG662699; EAR96035.2; -; Genomic_DNA.
DR RefSeq; XP_001016280.2; XM_001016280.2.
DR AlphaFoldDB; I7M7U7; -.
DR SMR; I7M7U7; -.
DR STRING; 312017.I7M7U7; -.
DR GeneID; 7846821; -.
DR KEGG; tet:TTHERM_00127000; -.
DR eggNOG; KOG1979; Eukaryota.
DR InParanoid; I7M7U7; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 225..348
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
SQ SEQUENCE 756 AA; 87128 MW; F096C2137F3C9066 CRC64;
MNHSQPLENT GPQIKKLPQE LIDKIAAGEV VQRPSAAVKE LIENCLDAGS SEISVGLVQG
GLKQLIVEDN GSGIHKDDFP LLCERFATSK INEFNDLQSL VSFGFRGEAL ASISFVSNLK
ITSRKPNSDL GYKASFKNGV MLGEEPEAVN CTEGTTVDVQ DLFFNYDARR KSLNVNEEKK
RVLKLIGQFA MHHAKLRFKF KSDNQIQFSS HSVLGSTELQ RREQIMQQIT KIADKSFTSC
ESESTEYQVK FKGTFSNIGA TKKYKEITLF INNRLVECES IKKAVERSYQ SCYQSIHEEE
GGYFCYLSLE MNPKNLDPNV HPTKKEVKFL FEYEIAKEIE SWIFENLKNC GVIKQLSANI
SQRTSSFETS NVKRSSSSQL YFGSQSNLSK QNSDYYQPTK QIRVDPRDQK ITRFFSVESS
EDGNNNSNQK NYQSINYIEE QKEEHLNSQD DIAEEPVDMI KKKKMLNEER NQTSISNIGS
SDQLDANNAR SSVIDRANSQ VNDPRIQVQQ QLLSLRNQDI HDTTSSFFKN LTYVGCISSN
HFLAQFRDDL YLINSIPLCQ EIFKFEILRN FGQIKPVELN QAIGLKDILE YFLLNFDEIP
NEKKEFHLSN MDTYIEQFGL LSDFLRDSVG IVIKDQKLLA FPNLFNLFEN DNNFKDISYI
LLRIITKVNF SEILQSGMGL ANELSFYFAW QLEKSFKNQL QRQHFQETQK QKWDDFFEQK
MLPMIKKKLS LPKLDISEFT VKLFKQEDAY KIFERC
//
