ID I7M7Z2_TETTS Unreviewed; 883 AA.
AC I7M7Z2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR96305.2};
GN ORFNames=TTHERM_00188740 {ECO:0000313|EMBL:EAR96305.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96305.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662693; EAR96305.2; -; Genomic_DNA.
DR RefSeq; XP_001016550.2; XM_001016550.2.
DR AlphaFoldDB; I7M7Z2; -.
DR GeneID; 7840445; -.
DR KEGG; tet:TTHERM_00188740; -.
DR InParanoid; I7M7Z2; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 75..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 262..366
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 709..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 103917 MW; B094D734A7916689 CRC64;
MNFNTSFFKQ GVINNNRIDI IKRYGKSKFW FDIIIVLPYI FGQNSQFYQS IFILRAFLIR
NIIHRLEEVF HPRNLGAALV DIIKVIFVIS FIAHLFCCSF YYLSTFETGQ TTWVTKLNLE
PNDIFGLYVA GVYYSVITMI TLGYGDIVPT TTVERIFVVG MTLVSCAVFA YSVNTISGII
GDFSSRKKYF RQKMMNLNLH IQKRGLNKQL AMTVRKYIEY LYKEEMVSNE SAEKDLEQIP
LSLKEDVYQD IYGKLLRQNK VFNLNFSLEF LDKLALKMKE KRFGPEEIIY REGDEGNTLY
FLIKGNVQLF LPIKGHKDNS YLQIQQLEKG TTFGFYSFFS GNNRETSARS MRVTSLVTLN
LEDFREAAEK FPKDYEKFCM LRDQIKYSNL TKGLDVRCTS CDNYTHQLQQ CPFLKYKPEK
TILIAKYNKS DPMQRKEQQR RIIRSPNSLF LLQFITKDDI YCFLNLDGSD SDNDHYHQEQ
EEAVDLEEQF NDKRTSYANV DDREDYNKIR DNTSQNYKDN YIKENSSIKE FNSNNNIKDQ
AYIESQQNKR QSTYHRIESS LSYKRKIMSQ HTTASNMAKQ ASKLTSRLSF RSQKIQIEKT
QNQVIMDFIL IDIDKLKSYQ NYLPQNNFEK VIQQYNESLI MQKVYKPKKQ LYQIVNKDRQ
KINLSKLRVI AAFKKVNKNQ QIITTKHKIE SQSRKKAILE QLKQHSEGNS DYLTYESNPN
KVNQNNNDIR EQKQSPESGK YEIKVLSHSK NSINSEKQPQ NDQENKNEGE IKQNNLLINQ
SCKSESALDQ DILSKSEDVD KIKYKILKKK KTSSFVVKPS QFYQENQAEE QEFSKDQIEQ
KRQKSHKQIH EAIMNYNMKR RSFSNIINNS SFTDIQQNDK DNN
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