GenomeNet

Database: UniProt
Entry: I7M820_TETTS
LinkDB: I7M820_TETTS
Original site: I7M820_TETTS 
ID   I7M820_TETTS            Unreviewed;       564 AA.
AC   I7M820;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=Eukaryotic aspartyl protease {ECO:0000313|EMBL:EAR96452.2};
GN   ORFNames=TTHERM_00191200 {ECO:0000313|EMBL:EAR96452.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96452.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG662693; EAR96452.2; -; Genomic_DNA.
DR   RefSeq; XP_001016697.2; XM_001016697.2.
DR   AlphaFoldDB; I7M820; -.
DR   STRING; 312017.I7M820; -.
DR   GeneID; 7832070; -.
DR   KEGG; tet:TTHERM_00191200; -.
DR   InParanoid; I7M820; -.
DR   OrthoDB; 1989790at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 2.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000313|EMBL:EAR96452.2};
KW   Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EAR96452.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          110..470
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          70..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        396..432
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   564 AA;  65935 MW;  5E847A5F668BCFFB CRC64;
     MKSIETKTLV KVSIILIFIS NTFQIIAAQR LPIKIPFQFA NNPSSKIKLS EADLRIKLIC
     QDMQVSPLKN LKKKDDDDDD EDDDDDDKKK YRNEDYFLKQ KDRTDLDFQY TTDFLIGSNK
     QKMTLLVDTG SQQSWIPTID CNEKTCPKYS HWFNYSQSSS YSQRKITQKI EYLSGDIQGY
     EGKDLILFKD SQQGQILVPL LFAYKVDSFI FTNFDGVLGL PNKIKSDSLI DILYDQNLID
     NPRFSIQIAR FPEPSSDKTR VLDNKDYKNI IQKGDDDDDD DEDDNDNNKQ EDNYLNDQYL
     NDKNSYLYIG QGIPKQILNK TNWVETTSSI QWKTILIGLY HNDNDLIDQL DSHNYDVYFE
     SGTSLSLFPE EIKEYLEELL IKKGCDKKNN QVYCDCNSDN YPKLQFYLRG VKLIFDSNIY
     FNKTKLSQKK QCLFNVLTSP EDHNFIVFGN SLIRKYLLTF DKKEQKVGFY NSQLVKNEST
     GIILIFLVNI IILGGLLYVI YETVRQEKTI KGEEDEDQEV FFQELEIYSN RSSFNSTYSR
     MFNPTLLDEQ SFNEGHRYCD MIKI
//
DBGET integrated database retrieval system