ID I7M820_TETTS Unreviewed; 564 AA.
AC I7M820;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Eukaryotic aspartyl protease {ECO:0000313|EMBL:EAR96452.2};
GN ORFNames=TTHERM_00191200 {ECO:0000313|EMBL:EAR96452.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96452.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; GG662693; EAR96452.2; -; Genomic_DNA.
DR RefSeq; XP_001016697.2; XM_001016697.2.
DR AlphaFoldDB; I7M820; -.
DR STRING; 312017.I7M820; -.
DR GeneID; 7832070; -.
DR KEGG; tet:TTHERM_00191200; -.
DR InParanoid; I7M820; -.
DR OrthoDB; 1989790at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000313|EMBL:EAR96452.2};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EAR96452.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..470
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 70..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 396..432
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 564 AA; 65935 MW; 5E847A5F668BCFFB CRC64;
MKSIETKTLV KVSIILIFIS NTFQIIAAQR LPIKIPFQFA NNPSSKIKLS EADLRIKLIC
QDMQVSPLKN LKKKDDDDDD EDDDDDDKKK YRNEDYFLKQ KDRTDLDFQY TTDFLIGSNK
QKMTLLVDTG SQQSWIPTID CNEKTCPKYS HWFNYSQSSS YSQRKITQKI EYLSGDIQGY
EGKDLILFKD SQQGQILVPL LFAYKVDSFI FTNFDGVLGL PNKIKSDSLI DILYDQNLID
NPRFSIQIAR FPEPSSDKTR VLDNKDYKNI IQKGDDDDDD DEDDNDNNKQ EDNYLNDQYL
NDKNSYLYIG QGIPKQILNK TNWVETTSSI QWKTILIGLY HNDNDLIDQL DSHNYDVYFE
SGTSLSLFPE EIKEYLEELL IKKGCDKKNN QVYCDCNSDN YPKLQFYLRG VKLIFDSNIY
FNKTKLSQKK QCLFNVLTSP EDHNFIVFGN SLIRKYLLTF DKKEQKVGFY NSQLVKNEST
GIILIFLVNI IILGGLLYVI YETVRQEKTI KGEEDEDQEV FFQELEIYSN RSSFNSTYSR
MFNPTLLDEQ SFNEGHRYCD MIKI
//