ID I7M965_TETTS Unreviewed; 719 AA.
AC I7M965;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Phosphatidylinositol 4-phosphate 5-kinase {ECO:0000313|EMBL:EAS00880.2};
GN ORFNames=TTHERM_00310510 {ECO:0000313|EMBL:EAS00880.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00880.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662608; EAS00880.2; -; Genomic_DNA.
DR RefSeq; XP_001021126.2; XM_001021126.2.
DR AlphaFoldDB; I7M965; -.
DR STRING; 312017.I7M965; -.
DR GeneID; 7842786; -.
DR KEGG; tet:TTHERM_00310510; -.
DR InParanoid; I7M965; -.
DR OrthoDB; 3676883at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16448; RING-H2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14155; RING FINGER DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14155:SF631; RING_U-BOX SUPERFAMILY PROTEIN; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 364..405
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 445..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 83198 MW; 382070D23A835EE7 CRC64;
MSLGSDAQQT GLVACVIASQ SDFISLSSVI KYLQTNEFDS DKKGSFQTFF IDYEGCSMQD
QIQYIQIKPP HLNNSYMFQI LNLSQSYQVF QVEIDIFFQS NSICLDQCSI DKYQNSQNTC
HESLCQCSDN YIGQRCQVHV NKFSDGEQNI QVEVKGFSWV FYELDLLKIQ NEYTLTVNDL
NQQIKYSIIE SGLSSYQVPS LYQGINVIDQ AGSYRLQNDI IQDYQAFASI NKSQQLSFLI
SFYNPSNQTL MFSFQFSSQL NQDDSSDEKV KTRNIIVIVV CLIASAVSIP IIYRVVNNFY
ASKQDIIIPS QPAPVSPYNI HLVQAQLQKK NGSLSKELIE KFMPAVFYAD LLTKYQNLKE
FSECMICLTD FEESNLCRMT VCYHLFHKNC LESWLELQDS CPFCRKELNK QTLEENKLQS
QENPYINRIV QSSNIQKTLS QDKNQEYPSF NDLGNRKNSQ QFSEKTNFTS QENSHFLSQS
PSSVSKNNKI DYNQADSVIQ DEQQDNNFFN VKNCNKSSEK EQENCSLRQS RIKISFLQQL
EGDEVGIQSN PQQLNTLFCE NFEKIKQQQN RISRLSIDNE EIMIEEPSKL NEEDSSCKAF
SKKNNEFYIQ QNSNQNEQSL IQKQSIESTQ QSTFNKQMSI YQITQQDHSN RIQINKSFSQ
LNKSEHIQQI NQNQQRFIQH SAQFNPVNKQ AKQLLNSKSN LEISQSKESK HSQDQIIIK
//
