ID I7MAI5_TETTS Unreviewed; 549 AA.
AC I7MAI5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=PHD-finger protein {ECO:0000313|EMBL:EAS04663.4};
GN ORFNames=TTHERM_00241840 {ECO:0000313|EMBL:EAS04663.4};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS04663.4, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662443; EAS04663.4; -; Genomic_DNA.
DR RefSeq; XP_001024908.4; XM_001024908.4.
DR AlphaFoldDB; I7MAI5; -.
DR STRING; 312017.I7MAI5; -.
DR GeneID; 7825310; -.
DR KEGG; tet:TTHERM_00241840; -.
DR InParanoid; I7MAI5; -.
DR OrthoDB; 5491253at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.1150; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46309; PHD FINGER PROTEIN 12; 1.
DR PANTHER; PTHR46309:SF1; PHD FINGER PROTEIN 12; 1.
DR Pfam; PF00628; PHD; 2.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 7..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 342..398
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 395..445
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 485..543
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 305..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 305..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 65342 MW; DDB90D26A7BF4D92 CRC64;
MQKLLKYICL FIVNYQLSSF ITNNFLHFLS LYKNLLNKKQ SERRLRNLNN KFLIQLDQIN
IYLLFLVSFL LERKKFFTHV DQMLNKFVLD KQTDRNFSPF DKYIFEQLHL NSNKINPFHT
DCKFTKRRVC YCNYHNSSLI EQRSQELNEA VNRYLKVDYS GATKQDLKRS LINRQLAQEK
VKRLQDLEDL FYMAPKYEKY VEAQKEEENA ILREQIIQEQ KNMIINGQCY YCQTTHSNKF
YEISPNPAET VVICEECAIS NHPEVVTYNN KPAQKPENLI EKKKKRQEAQ AKRLQTLQAK
KLLKMGTLDQ NSNKQNKQGN EKSTTKLDKE DDEDESDISE TQKECNWEKC KKKNKSDPED
ILVCKNCNKS FHAECCDPPL EKGIVSKYDW FCTECKLCIA CNKNTKENEL LMCDCCDRPF
HMSCLEPART DIPEGRWFCK DCEKCPCCGV LLFQNYSREL LKQYSKQQVD NKIICKDCWV
YYQQKKYCPI CFKIIEENAE GQFVYCDKCE LWLHYECEKK LSNRSFREIN RSKQFCCSKC
KVIEDSKQK
//
